Targeted nano drug delivery system co-carrying dtic and miRNA-34a and its preparation method and application
A drug delivery system and targeted technology, applied in the field of medicine, can solve the problems of low drug efficacy and strong side effects, and achieve the effects of high safety, significant drug efficacy and low cytotoxicity
Active Publication Date: 2022-05-31
JIAXING UNIV
View PDF2 Cites 0 Cited by
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
[0006] In view of the deficiencies and actual needs of the prior art, the present invention provides a targeted nano drug delivery system co-loading DTIC and miRNA-34a and its preparation method and application. Chemotherapy drugs and gene drugs are co-loaded in novel polypeptide micelles, overcoming The problem of low drug efficacy, strong side effects and drug resistance in the chemotherapy process has been solved, and the synergistic therapeutic effect on melanoma has been realized
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View moreImage
Smart Image Click on the blue labels to locate them in the text.
Smart ImageViewing Examples
Examples
Experimental program
Comparison scheme
Effect test
Embodiment 1
Embodiment 2
Embodiment 3
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More PUM
| Property | Measurement | Unit |
|---|---|---|
| particle diameter | aaaaa | aaaaa |
Login to View More
Abstract
The invention discloses a targeted nano drug delivery system co-loaded with DTIC and miRNA-34a and its preparation method and application. DTIC and miRNA‑34a in micelles. The present invention uses amphiphilic polylactic acid-polypeptide micelles as a drug-loading system to construct a targeted nano drug delivery system that co-loads the chemotherapy drug DTIC and the gene drug miRNA-34a, and the polylactic acid-polypeptide micelles mediate DTIC and miRNA-34a Evade RES clearance, effectively deliver DTIC and miRNA‑34a to the cytoplasm, play a synergistic role, inhibit melanoma cell proliferation and promote melanoma cell apoptosis, provide a new method for the treatment of melanoma, and provide a basis for the treatment of other tumors useful reference.
Description
Targeted nano-drug delivery system co-loaded with DTIC and miRNA-34a and preparation method thereof application technical field The invention belongs to the technical field of medicine, relate to the targeted nano drug delivery system of co-loading DTIC and miRNA-34a and its Preparation method and application. Background technique Malignant melanoma (MM) is a highly invasive, highly metastatic, and radiotherapy- and chemotherapy-insensitive malignant tumor Tumor is one of the most common malignant diseases in skin cancer, the 5-year survival rate is less than 5%, and the average median survival time is only 6 months. target There is currently no effective treatment for metastatic malignant melanoma (MMM). Cytotoxic dacarba oxazine (DTIC) for the treatment of metastatic malignant melanoma, however, DTIC is a poorly targeted DNA with strong side effects and a low response rate Alkylated preparations are the main cause of drug resistance, metastasis and recurrence...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More Application Information
Patent Timeline
Login to View More Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/107A61K31/7105A61K31/655A61K47/42A61K47/34A61K48/00A61P35/00
CPCA61K9/1075A61K31/7105A61K31/655A61K47/42A61K47/34A61P35/00A61K2300/00
Inventor 丁宝月张洁李明娟丁雪鹰顾圣莹武鑫唐人杰敖雷詹淑玉许伟斌吴凯凯胡楚玲王卓想
Owner JIAXING UNIV