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1,3-thiazol-2-yl substituted benzamides for the treatment of diseases associated with nerve fiber sensitization

A use, alkyl technology, applied in the field of chronic cough, treatment of diseases related to nerve fiber sensitization, treatment or prevention of diseases related to nerve fiber sensitization, can solve the problems of undocumented chronic cough treatment options, etc., to avoid Effects of Physiological Dependence

Pending Publication Date: 2021-02-05
BAYER AG +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0022] In summary, the prior art does not document any approved treatment options for chronic cough (CC) that can be used as long-term oral treatment
In addition, known treatments for chronic cough and other chronic upper respiratory diseases (eg, idiopathic pulmonary fibrosis (IPF), chronic obstructive pulmonary fibrosis (IPF), chronic obstructive chronic pulmonary disease (COPD) and asthma) have undesirable side effects such as physical dependence, increased heart rate, dry mouth, lethargy or sedation

Method used

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  • 1,3-thiazol-2-yl substituted benzamides for the treatment of diseases associated with nerve fiber sensitization
  • 1,3-thiazol-2-yl substituted benzamides for the treatment of diseases associated with nerve fiber sensitization
  • 1,3-thiazol-2-yl substituted benzamides for the treatment of diseases associated with nerve fiber sensitization

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Embodiment Construction

[0048] The terms as referred to herein preferably have the following meanings:

[0049] The terms "halogen atom", "halo-" or "halo-" are understood to mean fluorine, chlorine, bromine or iodine atoms, preferably fluorine or chlorine atoms.

[0050] The term "alkyl" is understood to mean a straight or branched chain saturated monovalent hydrocarbon group having the indicated number of carbon atoms and generally in the R 2 2 to 6 carbon atoms in the case of and 1 to 4 (preferably 1 to 3) carbon atoms for all other alkyl substituents, for example and preferably methyl, ethyl, propyl, butyl, pentyl base, hexyl, isopropyl, isobutyl, sec-butyl, tert-butyl, isopentyl, 2-methylbutyl, 1-methylbutyl, 1-ethylpropyl, 1,2-di Methylpropyl, neopentyl, 1,1-dimethylpropyl, 4-methylpentyl, 3-methylpentyl, 2-methylpentyl, 1-methylpentyl, 2-ethyl Dimethylbutyl, 1-ethylbutyl, 3,3-dimethylbutyl, 2,2-dimethylbutyl, 1,1-dimethylbutyl, 2,3-dimethylbutyl , 1,3-dimethylbutyl or 1,2-dimethylbutyl, or ...

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Abstract

The present invention relates to use 1,3-thiazol-2-yl substituted benzamide compounds of general formula (I) as described and defined herein, to pharmaceutical compositions and combinations comprisingsaid compounds for the treatment or prophylaxis of diseases which are associated with nerve fibre sensitization, in particular for treatment and prophylaxis of Chronic Cough (CC), Idiopathic Pulmonary Fibrosis (IPF), Chronic Obstructive Pulmonary Disorder (COPD), and asthma.

Description

[0001] The present invention relates to the use of 1,3-thiazol-2-yl-substituted benzamide compounds of general formula (I) as a single agent or in combination with other active ingredients and pharmaceutical compositions and combinations comprising said compounds for use in Use for the treatment or prophylaxis of diseases associated with sensitization of nerve fibers, in particular chronic cough. Background technique [0002] The present invention relates to the application of compounds inhibiting P2X3 receptors for treating diseases related to nerve fiber sensitization. P2X purinergic receptor 3 is a human protein encoded by the P2RX3 gene (Garcia-Guzman M, Stuehmer W, Soto F, 1997, Brain Res Mol Brain Res 47(1-2):59-66). The product of this gene belongs to the ATP purinoceptor family. This receptor acts as a ligand-gated ion channel and transduces ATP-induced nociceptor activation. [0003] P2X purinergic receptors are a family of ligand-gated ion channels activated by ATP...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/427A61P11/14A61P11/00A61P25/28A61P11/06
CPCA61K31/427A61P11/00A61P11/06A61P11/14A61P25/28A61K31/506A61K31/5377A61K9/0053
Inventor C·弗里德里希I·加绍D·伯劳克斯契尼德O·M·费舍尔
Owner BAYER AG
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