A method for electrochemically synthesizing 3-alkylselenyl-4-aminocoumarin compounds

A technology of aminocoumarin and synthesis method, which is applied in the field of electrochemically synthesizing 3-alkylselenyl-4-aminocoumarin compounds, can solve the problem of high cost, serious environmental pollution, and the inability to use 3-alkylselenyl-4 - Issues such as the synthesis of anilinocoumarin compounds, achieving the effects of reducing recovery steps, high reaction selectivity, and facilitating large-scale production
CN112359375BActive Publication Date: 2022-03-01HUNAN UNIV OF SCI & ENG
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
HUNAN UNIV OF SCI & ENG
Publication Date
2022-03-01

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Abstract

The invention discloses a method for electrochemically synthesizing 3-alkylselenyl-4-aminocoumarin compounds. The method is to use the solution containing 4-anilinocoumarin compound, dialkyl diselenide and bromine salt as the electrolyte, place a nickel anode and a graphite rod cathode in the electrolyte, feed in a direct current, and carry out electrolysis. 3-Alkylselenyl-4-anilinocoumarin compound can be obtained through chemical reaction; the method has the advantages of mild reaction conditions, simple operation, environmental protection, easy availability of raw materials, excellent compatibility of substrate functional groups, and high reaction yield.
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Description

technical field

[0001] The invention discloses a method for electrochemically synthesizing 3-alkylselenyl-4-aminocoumarin compounds. In particular, it relates to a method of electrochemically reacting 4-anilinocoumarin compound with dialkyl diselenide to synthesize 3-alkaselenyl-4- A method for an anilinocoumarin compound belongs to the technical field of organic intermediate synthesis. Background technique

[0002] 3-Alkylselenyl-4-anilinocoumarin compounds have a wide range of biological activities and play an important role in the field of drug research and development. And dialkyl diselenide is a kind of very easy-to-get raw material, utilizes dialkyl diselenide as selenization reagent, is prepared 3-alkane by the C-H bond aromatic selenylation reaction of 4-anilinocoumarin One of the ideal methods for seleno-4-anilinocoumarin derivatives.

[0003] In 2018, Yang Daoshan of Qingdao University of Science and Technology and others developed a synthesis method of 3-aryl s...

Claims

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