A kind of anticoagulant active peptide derivative and its preparation method and application

A technology of anticoagulant activity and peptide derivatives, applied in the field of biomedicine, can solve problems such as short half-life, and achieve the effects of long half-life, improved stability and strong antioxidant activity
CN112430254BActive Publication Date: 2021-10-26GUANGDONG OCEAN UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
GUANGDONG OCEAN UNIVERSITY
Publication Date
2021-10-26

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Abstract

The invention discloses an anticoagulant active peptide derivative, a preparation method and application thereof, and relates to the field of biomedicine. The amino acid sequence of the anticoagulant active peptide derivative is: X-Phe-Lys-His-Met-Asn-Glu. Wherein, the end group X is p-hydroxycinnamic acid, 2-amino-3-(2,3-dihydroxyphenyl)propionic acid and 2-amino-3-(4-hydroxy-3-methoxyphenyl) propane acid. The anticoagulant active peptide derivative prepared by the invention has high anticoagulant and thrombolytic activity, long half-life, high stability and strong antioxidative activity.
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Description

technical field

[0001] The invention belongs to the field of biomedicine, and in particular relates to an anticoagulant active peptide derivative and its preparation method and application. Background technique

[0002] Thromboembolic disease is known as the invisible killer of cardiovascular and cerebrovascular diseases. It can affect various organs and systems of the whole body. About 3‰ people suffer from different forms of thrombotic diseases every year. The number of people who die of cardiovascular and cerebrovascular diseases in my country reaches 3 million every year. More than 51% of the total annual death toll worldwide is caused by it. 75% of the surviving patients are disabled, and more than 40% of them are severely disabled, which seriously threatens human health.

[0003] Thrombus refers to a semi-clot-like substance formed on the surface of blood vessels or the intima of the heart during blood flow. Thrombotic diseases include arterial thrombosis, venous thro...

Claims

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