A method for consistency screening of magnetic nanoparticles

A technology of magnetic nanoparticles and screening methods, which is applied in chemical instruments and methods, wave energy or particle radiation treatment materials, pharmaceutical formulations, etc., can solve the problem of not being able to obtain magnetic nanoparticles with consistent particle sizes, and achieve stable and reliable methods. Improve the effect of treatment, economic and social benefits Huge effect

Active Publication Date: 2022-04-22
苏州易奥秘光电科技有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] In order to solve the problem that the prior art cannot obtain magnetic nanoparticles with consistent particle diameters, the present invention provides a consistent screening method for magnetic nanoparticles

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] A magnetic nanoparticle consistency screening method, comprising the steps of:

[0027] Step 1. Disperse magnetic nanoparticles of different particle sizes into hydroxyethyl acrylate and soak for a certain period of time; perform ball milling on the magnetic nanoparticles at a certain speed and ultrasonically disperse the magnetic nanoparticle mixture after ball milling at a certain power, Centrifuge the mixture after ultrasonic dispersion at high speed to collect magnetic nanoparticles;

[0028] Step 2, preparing a gelatin solution with a mass concentration of 10-35%, adding the magnetic nanoparticles collected in step 1 into the gelatin solution, heating the system to a certain temperature and performing ultrasonic dispersion treatment to obtain a gelatin suspension;

[0029] Step 3. The gelatin suspension obtained in step 2 is cooled from 95°C until the viscosity of the gelatin solution reaches 1,000 to 100,000 cps. As the temperature of the gelatin suspension decrea...

Embodiment 2

[0033] A magnetic nanoparticle consistency screening method, comprising the steps of:

[0034] Step 1. Disperse 10 to 30 g of magnetic nanoparticles with a particle size range of 5 to 200 nm in hydroxyethyl acrylate and soak for 30 to 50 minutes; ball mill the magnetic nanoparticles at a speed of 300 to 500 r / min, and the materials used for ball milling It is agate balls with a particle size of 2, 5, 10, 12 or 20mm. Under the ultrasonic power of 200-1000W and ultrasonic frequency of 1-40KHz, the magnetic nano particle mixture after ball milling is ultrasonically dispersed for 0.5-0.8h, and the ultrasonic The dispersed mixture is centrifuged at a high speed of 5000-10000r / min for 0.4-0.8h to collect magnetic nanoparticles;

[0035] Step 2, preparing a gelatin solution with a mass concentration of 10-35%, adding the magnetic nanoparticles collected in step 1 into the gelatin solution, heating the system to a certain temperature and performing ultrasonic dispersion treatment to o...

Embodiment 3

[0040] A magnetic nanoparticle consistency screening method, comprising the steps of:

[0041]Step 1. Disperse 10 to 30 g of magnetic nanoparticles with a particle size range of 5 to 200 nm in hydroxyethyl acrylate and soak for 30 to 50 minutes; ball mill the magnetic nanoparticles at a speed of 300 to 500 r / min, and the materials used for ball milling It is agate balls with a particle size of 2, 5, 10, 12 or 20mm. Under the ultrasonic power of 200-1000W and ultrasonic frequency of 1-40KHz, the magnetic nano particle mixture after ball milling is ultrasonically dispersed for 0.5-0.8h, and the ultrasonic The dispersed mixture is centrifuged at a high speed of 5000-10000r / min for 0.4-0.8h to collect magnetic nanoparticles;

[0042] Step 2. Prepare a gelatin solution with a mass concentration of 10-35%, add the magnetic nanoparticles collected in step 1 into the gelatin solution, heat the system to 60-95°C, and use 500-1000W ultrasonic power and 10-40KHz ultrasonic Frequency ult...

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PUM

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Abstract

The invention relates to a magnetic nanoparticle consistency screening method, which belongs to the technical field of tumor magnetic induction hyperthermia. In order to solve the problem that the existing technology cannot obtain magnetic nanoparticles with consistent particle sizes, the present invention provides a method for screening the consistency of magnetic nanoparticles, which involves dispersing magnetic nanoparticles with different particle sizes into an oily solution for ball milling, and centrifuging to collect magnetic nanoparticles. The particles are added to gelatin to prepare a gelatin suspension, and the gelatin suspension is cooled from 95°C. Magnetic nanoparticles of different particle sizes are suspended in different positions to form layers. Separate each layer of gelatin and heat the same layer of gelatin until it melts , centrifuged to obtain magnetic nanoparticles with consistent particle size. This application can flexibly select magnetic nanoparticles with required particle size from 5-200nm, solve the problem of screening and soft aggregation of magnetic nanoparticles of 20-40nm, and can provide ideal high-efficiency magnetic nanoparticle materials for tumor magnetic hyperthermia .

Description

technical field [0001] The invention belongs to the technical field of tumor magnetic induction hyperthermia, and in particular relates to a magnetic nanoparticle consistency screening method. Background technique [0002] The usual methods of tumor treatment are surgery, radiation, and chemotherapy. Surgery can remove the tumor lesions that are visible to the naked eye, and radiotherapy and chemotherapy are used for late treatment after surgery. The current chemotherapy has problems such as poor targeting and high toxicity, while radiotherapy has problems such as inaccurate dose control and large damage to normal tissues. Heat therapy is a new treatment method after surgery, radiotherapy and chemotherapy. Heat therapy technology includes radio frequency heat therapy, microwave heat therapy, photothermia therapy, magnetic heat therapy and other new treatment methods. [0003] Tumor magnetic hyperthermia is a kind of magnetic nanomaterials introduced into the tumor in the b...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B03B5/44A61K41/00A61P35/00
CPCB03B5/442A61K41/0052A61P35/00
Inventor 张洪泉孙伟民张凯张大昕田赫王勃然
Owner 苏州易奥秘光电科技有限公司
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