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Meglumine production process

A production process and technology of meglumine, applied in the field of meglumine production technology, can solve the problems of slow reaction, low production efficiency, etc., and achieve the effects of improving conversion rate, improving production efficiency, and high catalytic efficiency

Active Publication Date: 2021-03-12
弘健制药(上海)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Its reaction is slow and the production efficiency is low

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example 1

[0039] The preparation steps of skeleton nickel are:

[0040] In the aluminum-nickel-chromium-rhodium alloy, by parts by weight, aluminum is 39%, nickel is 48%, chromium is 7%, rhodium is 6%, and the aluminum-nickel-chromium-rhodium alloy is 80-100 mesh.

[0041] The preparation steps of the aluminum-nickel-chromium-rhodium alloy are: melting aluminum at 800°C, melting rhodium, nickel, and chromium at a temperature of 2500°C, and then adding the molten rhodium, nickel, and chromium to the molten aluminum, stirring evenly, and cooling , and then the alloy is melted, sprayed, and rapidly cooled by a spray method to obtain an aluminum-nickel-chromium-rhodium alloy.

[0042] Stir the 23wt% sodium hydroxide solution and raise the temperature to 47°C, then gradually add Al-Ni-Cr-R alloy powder, the mass ratio of Al-Ni-Cr-R alloy to lye is 1:4.5, naturally raise the temperature to 100°C, and keep at this temperature for 2.5 After one hour, let cool to 65°C, stop stirring, wash repea...

preparation example 2

[0044] The difference from Preparation Example 1 is that in the aluminum-nickel-chromium-rhodium alloy, in parts by weight, aluminum is 50%, nickel is 40%, chromium is 3%, and rhodium is 7%.

[0045] Stir the 25wt% sodium hydroxide solution and raise the temperature to 43°C, then gradually add the Al-Ni-Cr-R alloy powder, the mass ratio of the Al-Ni-Cr-R alloy to the lye is 1:5, naturally raise the temperature to 90°C, and keep the temperature at 2.6 After one hour, let cool to 60°C, stop stirring, wash repeatedly with water until pH is 7, then wash with absolute ethanol until the content of ethanol in the feed liquid is 96% and discharge.

preparation example 3

[0047] The difference with Preparation Example 1 is:

[0048] The difference from Preparation Example 1 is that in the aluminum-nickel-chromium-rhodium alloy, by weight parts, aluminum is 52%, nickel is 38%, chromium is 2%, and rhodium is 8%.

[0049] Stir the 28wt% sodium hydroxide solution and raise the temperature to 40°C, then gradually add the aluminum-nickel-chromium-rhodium alloy powder, the mass ratio of the aluminum-nickel-chromium-rhodium alloy to the lye is 1:5.5, naturally heat up to 85°C, and keep at this temperature for 3 After one hour, let cool to 55°C, stop stirring, wash repeatedly with water until pH is 7, then wash with absolute ethanol until the content of ethanol in the feed liquid is 98% and discharge.

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Abstract

The invention relates to a meglumine production process which comprises the following steps: S1, condensing monomethylamine with glucose in absolute ethyl alcohol to obtain a Schiff's salt; s2, addinga catalyst and absolute ethyl alcohol into the Schiff's salt, introducing hydrogen to react to obtain hydride, performing crystallizing to obtain solid hydride, adding water to melt the hydride, adding disodium ethylene diamine tetraacetate, carrying out concentrating under reduced pressure, carrying out centrifugal filtration to obtain a meglumine crude product, and purifying the meglumine crudeproduct, wherein the catalyst is skeleton nickel, and the preparation method of the skeleton nickel comprises the following steps: stirring liquid caustic soda, performing heating to 40-47 DEG C, gradually adding aluminum-nickel-chromium-rhodium alloy powder, naturally performing heating to 85-100 DEG C, keeping the temperature for 2.5-3 hours, performing cooling to 55-65 DEG C, stopping stirring, and performing washing with water and absolute ethyl alcohol. The meglumine production process has the effect of improving the meglumine production efficiency.

Description

technical field [0001] The application relates to the field of meglumine production, in particular to a meglumine production process. Background technique [0002] Meglumine, also known as glucose methylamine or 1-deoxy-1-methylamine sorbitol, is used for the preparation of contrast agent drugs diatrizoate meglumine and biliary meglumine, and is also used as an adjuvant or intermediate for other drugs. [0003] In the related technology, glucose is firstly condensed with methylamine in absolute ethanol to form Schiff's salt, hydrogen is used as hydrogen source, Raine's nickel is used as catalyst to synthesize meglumine, and it is produced by catalytic hydrogenation. [0004] Its reaction is slow and production efficiency is low. Contents of the invention [0005] In order to improve the production efficiency of meglumine, the application provides a production process of meglumine. [0006] A kind of meglumine production technique provided by the application adopts the fo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C213/02B01J23/89C07C215/10
CPCC07C213/02B01J23/8993C07C215/10Y02P20/584
Inventor 卿文彬张征彬李琳周秋火柏挺华吉涛
Owner 弘健制药(上海)有限公司
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