Preparation method of nanometer targeted drug, and application of nanometer targeted drug for treating gastric carcinoma

A nano-drug, targeting technology, applied in the field of biomedicine, to achieve the effects of good application prospects, high emission quantum yield, and excellent sustained release
CN112494660APending Publication Date: 2021-03-16SHANGHAI JIAO TONG UNIV +4
2 Cites 1 Cited by

Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
SHANGHAI JIAO TONG UNIV
Publication Date
2021-03-16

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention relates to the technical field of biological medicines, in particular to a preparation method of a nanometer targeted drug, and application of the nanometer targeted drug for treating gastric carcinoma. Two types of different nanometer drugs are prepared, and main nano-carriers are gold nanoparticles (GNP) and zinc sulfide quantum dots (ZnS QD), and are coupled with Adriamycin and ligand transferrin to carry out targeting on the protein tumor cell of a transferrin receptor which is in high expression on gastric carcinoma cells or the stomach. The nano-carrier gold nanoparticle (GNP) is a most compatible nanostructure which has better advantages than other metal nanometer composite materials, and the zinc sulfide quantum dot (ZnS QD) is a very important quantum dot nanoparticle, has small toxicity, is friendly to human and has a narrow-band spectrum. The prepared two therapeutic nanometer drugs have good stability, a high drug loading capacity and good slow-release properties, can enhance medicine targeting concentration, enhance a tumor killing treatment effect and lower a non-specific toxic and side effect. The design way of the two therapeutic nanometer drugs can beused for gastric carcinoma diagnosis, gastric carcinoma treatment and gastric carcinoma prognosis, and an application prospect is good.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The invention relates to the technical field of biomedicine, in particular to a preparation method of a nano-targeted drug and its application in treating gastric cancer. Background technique

[0002] Of all the dreadful diseases, cancer is the leading cause of death worldwide and their incidence is increasing worldwide. Among the different types of cancer, gastric cancer is one of the most prevalent cancers with the highest mortality rate, gastric cancer may be caused by diet, organic solvents, insecticides and pesticides, gastric cancer is also directly related to many factors such as high salt in diet Intake or infection with microorganisms such as Helicobacter pylori (H. pylori), which is caused by the infection of the stomach wall by microorganisms such as Helicobacter pylori or caused by certain genetic changes. Currently, various imaging techniques are being used for cancer diagnosis, such as single photon emission tomography, magnetic resonanc...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More