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Preparation method of polyanhydride modified controllable biodegradable calcium phosphate bone cement as well as product and application thereof

A calcium phosphate bone cement, biodegradable technology, applied in tissue regeneration, medical science, prosthesis, etc., can solve the problems of slow degradation rate, prolonging the self-healing time of repaired parts, mismatching of material degradation rate and new bone growth rate, etc. Achieve the effects of promoting degradation, facilitating production expansion, and controlling the rate

Pending Publication Date: 2021-03-26
SHANGHAI NAT ENG RES CENT FORNANOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, because the products formed by the solidification of calcium phosphate bone cement, such as hydroxyapatite, calcium-deficient hydroxyapatite, etc., have a slow degradation rate in the body, clinically often encounter the problem that the degradation rate of the material does not match the growth rate of new bone , prolong the self-healing time of the repaired part

Method used

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  • Preparation method of polyanhydride modified controllable biodegradable calcium phosphate bone cement as well as product and application thereof
  • Preparation method of polyanhydride modified controllable biodegradable calcium phosphate bone cement as well as product and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] A controllable biodegradable calcium phosphate bone cement modified by polyanhydride. Alpha-tricalcium phosphate (α-TCP) is prepared by solid-state reaction method as the main component of calcium phosphate bone cement powder; a certain proportion of The polyanhydride powder is fully mixed and prepared to obtain bone cement powder; the bone cement powder is mixed with the solidification solution containing disodium hydrogen phosphate according to a certain solid-liquid ratio, and solidified to obtain calcium phosphate bone cement. By controlling the chemical composition and ratio of polyanhydride , to realize the control of the biodegradation rate of bone cement, prepared according to the following steps:

[0025] (1) Preparation of α-TCP: Mix calcium hydrogen phosphate and calcium carbonate at a molar ratio of 2:1, use pure water as the medium for wet ball milling, rotate at 400 rpm, mill for 4 hours, and the mass ratio of milling beads to powder is 2:1 1. After drying...

Embodiment 2

[0031] A polyanhydride-modified controllable biodegradable calcium phosphate bone cement, which is the same as step (1) in the embodiment, prepared according to the following steps:

[0032] The α-TCP prepared in Example 1 (1) was mixed with polysebacic anhydride at a mass ratio of 9:1, and the mixing method was dry ball milling at 150 rpm in an agate ball mill jar to obtain bone cement powder;

[0033] The bone cement powder was mixed with 2.5% disodium hydrogen phosphate solution at 2 g / mL, and the initial setting time was determined to be 11 min with reference to the standard ASTM C191.

Embodiment 3

[0035] A polyanhydride-modified controllable biodegradable calcium phosphate bone cement, which is the same as step (1) in the embodiment, prepared according to the following steps:

[0036] The α-TCP prepared in Example 1 (1) was mixed with polyanhydride p (CPP-co-SA) at a mass ratio of 95:5, and the mixing method was dry ball milling in an agate ball mill jar at 150rpm to obtain bone cement powder ;

[0037] The bone cement powder was mixed with 2.5% disodium hydrogen phosphate solution at 2 g / mL, and the initial setting time was determined to be 10 min with reference to the standard ASTM C191.

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Abstract

The invention relates to a preparation method of polyanhydride modified controllable biodegradable calcium phosphate bone cement, which comprises the following steps: preparing alpha-tricalcium phosphate (alpha-TCP) as a main component of calcium phosphate bone cement powder by a solid-state reaction method; adding a certain proportion of polyanhydride powder into the powder, and fully and uniformly mixing to prepare bone cement powder; and blending the powder with a solidified liquid containing disodium hydrogen phosphate according to a certain solid-to-liquid ratio, and solidifying to obtainthe calcium phosphate bone cement. The regulation and control of the biodegradation rate of the bone cement are realized by controlling the chemical components and proportion of the polyanhydride. According to the invention, polyanhydride is used as a modifier, and an acidic degradation product of polyanhydride can reduce the pH value around the material, promote degradation of calcium phosphateand realize controllable biodegradation rate of bone cement. The used materials are good in biocompatibility, the preparation method is simple, expanded production is facilitated, and wide applicationprospects are achieved.

Description

technical field [0001] The invention relates to a method in the technical field of biomedical materials, in particular to a preparation method of a polyanhydride-modified controllable biodegradable calcium phosphate bone cement and its product and application. Background technique [0002] Calcium phosphate bone cement has attracted great attention as a substitute material for clinical bone repair because of its good biocompatibility, osteoconductivity, osteoinductivity and biodegradability [Apelt D, Biomaterials, 2004]. However, because the products formed by the solidification of calcium phosphate bone cement, such as hydroxyapatite, calcium-deficient hydroxyapatite, etc., have a slow degradation rate in the body, clinically often encounter the problem that the degradation rate of the material does not match the growth rate of new bone , Prolong the self-healing time of the repaired part. [0003] Polyanhydride is a biodegradable biomaterial approved by the US FDA that ca...

Claims

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Application Information

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IPC IPC(8): A61L27/12A61L27/18A61L27/50A61L27/58
CPCA61L27/12A61L27/18A61L27/50A61L27/58A61L2430/02C08L73/02
Inventor 崔大祥杨迪诚徐艳朱君
Owner SHANGHAI NAT ENG RES CENT FORNANOTECH
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