Single-particle rapid identification device and method based on femtosecond laser modulation phase
A femtosecond laser, modulated phase technology, applied in the field of optical imaging, can solve the problems of inability to achieve in-situ non-destructive testing, inability to achieve living body detection, etc.
Active Publication Date: 2021-03-26
SHANXI UNIV
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These methods have very high spatial resolution, but the sample needs to be specially prepared, which cannot realize in situ non-destructive testing, especially in vivo detection
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[0043] The present invention will be further described below with reference to the accompanying drawings and embodiments.
[0044] like figure 1 As shown, a single particle rapid identification device based on femtosecond laser modulation phase in this embodiment includes a femtosecond laser double beam preparation system 101, a laser self-interference light intensity detection system 102, and a multiphoton fluorescence excitation and collection system. 103. Four parts of the data extraction and processing system 104;
[0045] The femtosecond laser dual beam preparation system 101 includes a femtosecond laser 105, a polarizer 106, a mirror 107, an equal-ratio beam mirror 108, a first corner cube mirror 110, and a second corner cube mirror 112 , an electro-optical modulation crystal 113 and an electro-optical modulation crystal controller 114;
[0046] The femtosecond laser 105 is used to excite metal nanoparticles to generate multiphoton fluorescence, and the center waveleng...
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Abstract
The invention relates to a single particle rapid identification device and method based on femtosecond laser modulation phase, and aims to overcome the limitation that a single metal nanoparticle cannot be identified by traditional optical imaging, and utilize femtosecond laser to excite and modulate a multi-photon fluorescence process of the metal nanoparticle. By comparing the femtosecond laserself-interference phase with the multi-photon fluorescence modulation phase of the metal nanoparticles, the identification of the single metal nanoparticle is achieved. The single particle rapid identification device is composed of a femtosecond laser double-beam preparation system, a laser self-interference light intensity detection system, a multi-photon fluorescence excitation and collection system and a data extraction and processing system. Compared with the traditional dark field imaging and fluorescence imaging, the single metal nanoparticle can be identified without breaking through the diffraction limit. Compared with characterization methods such as a scanning electron microscope and an atomic force microscope, the method has the advantages that a sample does not need to be specially prepared, measurement under a vacuum condition is not needed, in-situ nondestructive detection can be realized, and the detected sample can be continuously subjected to other measurement or application.
Description
technical field [0001] The invention belongs to the technical field of optical imaging, and in particular relates to a single particle fast identification device and method based on femtosecond laser modulation phase. Background technique [0002] Noble metal nanoparticles, such as gold and silver nanoparticles, have localized surface plasmon resonance (LSPR for short). LSPR can localize the incident electromagnetic wave in the nanoscale range, significantly increase the intensity of the electromagnetic wave, and realize the amplification and modulation of optical signals. At the same time, metal nanoparticles have good luminescent properties, photostability and biocompatibility, so metal nanoparticles have important applications in biomedicine, chemical reaction tracing, analysis and sensing. [0003] The size of metal nanoparticles is usually below 100nm. Identifying the number and aggregation state of metal nanoparticles, such as single particles, dimers, polymers, etc.,...
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Login to View More IPC IPC(8): G01N21/64G01J1/00G01N21/01
CPCG01N21/6402G01J1/00G01N21/01Y02A90/10
Inventor 秦成兵李耀陈瑞云韩双萍张国峰胡建勇景明勇肖连团贾锁堂
Owner SHANXI UNIV