Gold-polyacid catalyst for color development detection of dopamine and preparation method of catalyst

An acid catalyst and dopamine technology, applied in chemical instruments and methods, physical/chemical process catalysts, chemical/physical processes, etc., can solve the problems of low method and selective application limitations, and achieve accurate color detection, high sensitivity, The effect of high catalytic activity

Active Publication Date: 2021-03-30
BEIHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The determination of dopamine in human serum by gold nanoparticles has also been reported before, and although conceptually simple, the developed method is often limited by low selectivity and application in practical systems

Method used

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  • Gold-polyacid catalyst for color development detection of dopamine and preparation method of catalyst
  • Gold-polyacid catalyst for color development detection of dopamine and preparation method of catalyst
  • Gold-polyacid catalyst for color development detection of dopamine and preparation method of catalyst

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Experimental program
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preparation example Construction

[0025] AU-PW 9 Cu 4 Preparation method

[0026] 3 g of 4 octyl bromide was dissolved in 16 ml of toluene, and 0.153 mmol·L was added to this solution. -1 Haucl 4 After 10 min, 72.4 μl of thiol was added to this solution, stirred at 0 ° C for 10 min, 76 mgnabh 4 The solution was dissolved in 5 ml of deionized water to form a solution, stirred at 0 ° C for 30 min, stirred at room temperature for 3 hours, collecting the organic phase with a rotary evaporator to remove the solvent, dissolved in 50 ml of n-hexane filtered, rotary evaporation and removal solvent, After the addition of 40 ml of ethanol was washed three times, it was dissolved in 15 ml of toluene and 0.01 ~ 0.15 GK 10 [Cu 4 (H 2 O) 2 (PW 9 O 34 ) 2 ] · 20h 2 O (PW 9 Cu 4 The aforementioned solution was dissolved in 10 ml of toluene, and a solution of 1: x (1 to 15) was obtained, and the mixture was stirred at room temperature for 1 hour, and the solvent was rotated at 40 ° C, and then dried in vacuo to give a dark gray po...

Embodiment 1

[0029] 3 g of 4 octyl bromide was dissolved in 16 ml of toluene, and 0.153 mmol·L was added to this solution. -1 Haucl 4 After 10 min, 72.4 μl of thiol was added to this solution, stirred at 0 ° C for 10 min, 76 mgnabh 4 The solution was dissolved in 5 ml of deionized water to form a solution, stirred at 0 ° C for 30 min, stirred at room temperature for 3 hours, collecting the organic phase with a rotary evaporator to remove the solvent, dissolved in 50 ml of n-hexane filtered, rotary evaporation and removal solvent, After adding 40 ml of ethanol, then dissolved in 15 ml of toluene, 0.05 GK 10 [Cu 4 (H 2 O) 2 (PW 9 O 34 ) 2 ] · 20h 2 O (PW 9 Cu 4 The aforementioned solution was dissolved in 10 ml of toluene to obtain a solution of 1: 5 ratio of solution, and the mixture was stirred at room temperature for 1 hour, and the solvent was rotated at 40 ° C. After the vacuum dried, it was calcined at 300 ° C to obtain dark gray powder, that is, Au-Pw 9 Cu 4 (1: 5) Selective color catalys...

Embodiment 2

[0032] 3 g of 4 octyl bromide was dissolved in 16 ml of toluene, and 0.153 mmol·L was added to this solution. -1 Haucl 4 After 10 min, 72.4 μl of thiol was added to this solution, stirred at 0 ° C for 10 min, 76 mgnabh 4 The solution was dissolved in 5 ml of deionized water to form a solution, stirred at 0 ° C for 30 min, stirred at room temperature for 3 hours, collecting the organic phase with a rotary evaporator to remove the solvent, dissolved in 50 ml of n-hexane filtered, rotary evaporation and removal solvent, After adding 40 ml of ethanol, then dissolved in 15 ml of toluene, 0.09 GK 10 [Cu 4(H 2 O) 2 (PW 9 O 34 ) 2 ] · 20h 2 O (PW 9 Cu 4 The aforementioned solution was dissolved in 10 ml of toluene to give a solution of 1: 9 ratio of solution. After stirring at room temperature for 1 hour, 40 ° C was evaporated to remove the solvent. After vacuum dried, it was calcined at 300 ° C to obtain dark gray powder, that is, Au-Pw 9 Cu 4 (1: 9) Selective test detection of polyacid ...

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Abstract

The invention relates to a polyacid catalyst for color development detection of dopamine. The general formula of a gold-polyacid compound is Au-PW9Cu4(1:x) (x=1-15). The preparation method of the catalyst comprises the following steps: dissolving tetraoctylammonium bromide in toluene, adding HAuCl4, conducting stirring, adding mercaptan into the solution, conducting stirring, dissolving NaBH4 in deionized water, adding a formed solution into the previous solution, conducting stirring, collecting an organic phase, removing the solvent by using a rotary evaporator, dissolving a solid in n-hexane, conducting filtering, carrying out rotary evaporation to remove the solvent, and adding ethanol for washing for three times; and dissolving a treated solid in toluene, dissolving K10[Cu4(H2O)2(PW9O34)2].20H2O in toluene, adding a formed K10[Cu4(H2O)2(PW9O34)2].20H2O solution into a formed solution of the solid to obtain solutions, conducting stirring, carrying out rotary evaporation to remove the solvent, carrying out vacuum drying, and conducting calcining to obtain dark gray powder, thereby obtaining the product. The catalyst has high catalytic activity, stability and selectivity, and dopamine can be detected through color change observed by naked eyes.

Description

Technical field [0001] The present invention is a catalyst preparation and application technique, and more particularly to a polyacid catalyst which is developing a dopamine. [0002] technical background [0003] Dopamine (DA) is a special neurotransmitter in the human brain, which is the basis of brain function. The neurological disorder of brain dopamine is an important reason for the cause of schizophrenia and Parkinson's disease. In addition, dopamine can irritate hearts for ischemic, cardiogenic and septic shock. The study of dopamine analysis methods is of great significance to the neurophysiological function, disease diagnosis and quality control of related drugs. [0004] At present, some methods of detecting dopamine have been developed, such as electrochemical analysis, high performance liquid chromatography (HPLC) and chemiluminescence, but these methods involve complex sample processing procedures and poor reproducibility, in the past In the past ten years, people hav...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J27/188G01N21/78
CPCB01J27/188G01N21/78
Inventor 段喜鑫柏智先韩永蔚时君友
Owner BEIHUA UNIV
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