A Dispersion Compensation Method Based on Fourier Domain Optical Coherence Tomography

Abstract

The invention discloses a dispersion compensation method based on Fourier domain optical coherence tomography technology, which belongs to the technical field of optical coherence tomography. The invention obtains the interference signal according to the light intensity signal of the output light of the Fourier domain optical coherence tomography system, and then transforms the interference signal to obtain a complex interference signal, that is, an analytical signal, and then extracts the relationship between the phase and the wave number and performs a third-order polynomial simulation. Finally, use the calculated second-order and third-order dispersion factors to perform phase compensation on the analytical signal to achieve the effect of eliminating the effect of high-order dispersion in the Fourier domain optical coherence tomography system, and to improve the Fourier domain optical coherence layer. The purpose of analyzing the axial resolution of the imaging system. The operation mode of the invention is simple, and the dispersion compensation in the continuous real-time imaging can be realized only by measuring and calibrating once in the experiment.

Description

technical field [0001] The invention belongs to the technical field of optical coherence tomography, and relates to a dispersion compensation method based on Fourier domain optical coherence tomography. Background technique [0002] Optical coherence tomography (OCT) technology is a mainstream optical imaging technology, which has the advantages of high resolution, non-contact and real-time imaging, and is widely used in biomedicine and medical fields. The first generation of OCT technology is time domain OCT (time domain OCT, TD-OCT). The axial scanning of the sample is realized by mechanically moving the mirror of the reference arm. The imaging speed of this scanning method is limited by the scanning speed, and it will also The introduction of scanning noise limits the development of TD-OCT technology. The second-generation OCT technology is Fourier domain OCT (fourier domain OCT, FD-OCT), including spectral domain OCT (spectral domain OCT, SD-OCT) and swept frequency dom...

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Problems solved by technology

[0005] In view of the above-mentioned dispersion mismatch problem in Fourier domain OCT, as well as the disadvantages of the traditional hardware compensation method, such as the need to measure the refractive index of the sample, resulting in high cost, and the large amount of calculation in the traditional software compensation method, the present invention proposes a Based on the dispersion compensation method of Fourier domain optical coherence tomography technology, the relationship between phase and wavenumber is obtained by processing the interference signal, and the third-order polynomial fitting is performed on the phase and wavenumber to obtain high-order dispersion factors for phase compensation. , thereby eliminating the influence of high-order dispersion and improving the axial resolution of the Fourier domain OCT system

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