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Multi-mode imaging system and method based on photoacoustic and optical coherence tomography

An optical coherence tomography, multimodal imaging technology, applied in the field of medical imaging, can solve the problems of limited observation ability, difficult to obtain multi-element information of biological tissue, etc., and achieve the effect of high sensitivity

Pending Publication Date: 2021-06-08
SHENZHEN UNIV
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Problems solved by technology

[0006] In view of the above defects in the prior art, the present invention provides a multimodal imaging system and method based on photoacoustic and optical coherence tomography, aiming to solve the limitations of the two single imaging mechanisms of existing OCT imaging and photogenerated imaging Due to their own observation capabilities, they can only measure the optical properties of samples from a single side, and it is difficult to obtain multi-element information of biological tissues.

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[0040] The present invention will be further described in detail below through specific embodiments in conjunction with the accompanying drawings. Apparently, the described embodiments are only some, not all, embodiments of the present application. It should be understood that the specific embodiments described here are only used to explain the present invention, not to limit the present invention. In the following implementation manners, many details are described for better understanding of the present application. However, those skilled in the art can readily recognize that some of the features can be omitted in different situations, or can be replaced by other elements, materials, and methods. In some cases, some operations related to the application are not shown or described in the description, this is to avoid the core part of the application being overwhelmed by too many descriptions, and for those skilled in the art, it is necessary to describe these operations in de...

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Abstract

The invention provides a multi-mode imaging system and method based on photoacoustic and optical coherence tomography. The multi-mode imaging system based on the photoacoustic and optical coherence tomography technology comprises an OCT imaging device, a photoacoustic imaging device, a sample placing device and a control and signal processing device. The OCT imaging device comprises a first light source, a first light transmission device and a first light signal detection device; the photoacoustic imaging device comprises a second light source, a second light transmission device, a photoacoustic sensing device and a second light signal detection device; and the photoacoustic sensing device is based on the surface plasma resonance sensing technology and comprises a third light source, a first light polarization device, a prism, a photoacoustic wave coupling solution, a concave surface acoustic wave reflector and a second light polarization device. According to the multi-mode imaging system, photoacoustic imaging and OCT imaging are effectively fused, 'label-free, multi-view and self-registration 'observation of tissues is achieved, and an innovative technical means is provided for exploring a complex physiological and pathological mechanism of an organism.

Description

technical field [0001] The invention relates to the technical field of medical imaging, in particular to a multimodal imaging system and method based on photoacoustic and optical coherence tomography. Background technique [0002] As we all know, biological tissue is a complex system including cells, extracellular matrix, blood microcirculation and many other elements, such as skin, retina, neurovascular coupling, malignant tumors, etc. Obtaining multi-angle and all-round information of biological tissues is the prerequisite for realizing accurate evaluation of the physiological and pathological state of the body. [0003] Among the many optical microscopy techniques, optical coherence tomography (OCT) and photoacoustic imaging, with their unique imaging contrast mechanism, combined with multiple advantages such as label-free, fast, and in vivo observation, are used in It has its own advantages in distinguishing tissue layered structure and observing blood microcirculation....

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/17G01N21/45G01N21/552
CPCG01N21/1702G01N21/45G01N21/553G01N2021/1734
Inventor 李光宋伟闵长俊袁小聪
Owner SHENZHEN UNIV
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