Albendazole ivermectin powder and preparation method thereof

A technology of albendazole ivermectin powder and albendazole, applied in the field of medicine, can solve the problems of poor stability and dispersibility, influence insecticidal effect, poor palatability, etc. Insecticidal effect, palatability improvement effect

Pending Publication Date: 2021-04-09
四川乾通动物药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The technical problem to be solved by the present invention is: the existing albendazole ivermectin has poor stability and dispersibility, poor palatability, and affects insecticidal effect. The invention provides a kind of albendazole ivermectin that solves the above problems Bendazolin ivermectin powder and preparation method thereof

Method used

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  • Albendazole ivermectin powder and preparation method thereof
  • Albendazole ivermectin powder and preparation method thereof
  • Albendazole ivermectin powder and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0025] A kind of albendazole ivermectin powder provided in this embodiment, raw material composition comprises by weight: 6.0 parts of albendazole, 1.3 parts of ivermectin, 32.0 parts of buffering agent, 55.0 parts of starch and flavoring 5.7 parts of the agent.

[0026] The preparation method step of above-mentioned albendazole ivermectin powder is:

[0027] Step 1: Add albendazole to the buffer, stir and mix evenly;

[0028] Step 2: Add ivermectin to starch, stir and mix evenly;

[0029] Step 3: Add the mixed powder of ivermectin and starch into the mixed powder of albendazole and buffer, stir and mix, then add maltol, continue to stir and mix evenly;

[0030] Step 4: crush the mixture added with maltol and sieve it to 180 meshes to obtain albendazole ivermectin powder.

Embodiment 2

[0032] The difference of this embodiment is that in embodiment 1, the raw material composition ratio of albendazole ivermectin powder is different, and the rest are the same as in embodiment 1.

[0033] A kind of albendazole ivermectin powder provided in the present embodiment 2, raw material composition comprises by weight: 14.0 parts of albendazole, 0.5 part of ivermectin, 35.0 parts of buffering agent, 45.0 parts of starch and 5.5 parts of flavoring agent.

Embodiment 3

[0035] The difference of this embodiment is that in embodiment 1, the raw material composition ratio of albendazole ivermectin powder is different, and the rest are the same as in embodiment 1.

[0036] A kind of albendazole ivermectin powder provided in the present embodiment 2, raw material composition comprises by weight: 18.0 parts of albendazole, 0.2 part of ivermectin, 27.0 parts of buffering agent, 50.0 parts of starch and 4.8 parts of flavoring agent.

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PUM

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Abstract

The invention discloses albendazole ivermectin powder and a preparation method thereof. The problems that existing albendazole ivermectin is poor in stability and dispersity and poor in palatability and influences the insecticidal effect can be solved. The albendazole ivermectin powder is prepared from the following raw materials of, in parts by weight, 6.0-18.0 parts of albendazole, 0.2-1.3 parts of ivermectin, 25.0-40.0 parts of a buffering agent, 45.0-55.0 parts of starch and 3.5-6.0 parts of a flavoring agent; the flavoring agent is maltol; and the starch is soluble starch. The albendazole ivermectin powder has the advantages of improved stability, improved dispersibility, good palatability and the like.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to an albendazole ivermectin powder and a preparation method thereof. Background technique [0002] Albendazole is a benzimidazole derivative, which is rapidly metabolized into sulfoxide, sulfone alcohol and 2-amine sulfone alcohol in the body. For intestinal nematodes, selectively and irreversibly inhibit the polymerization of the cytoplasmic microtubule system of the intestinal wall cells of the parasite, block its uptake and absorption of various nutrients and glucose, lead to the depletion of endogenous glycogen in the worm, and inhibit the reduction of fumaric acid The enzyme system prevents the production of adenosine triphosphate, so that the worm cannot survive and reproduce. Similar to mebendazole, albendazole can also cause the degeneration of the cytoplasmic microtubules of the enterocytes of the worm body, and bind to its tubulin, causing intracellular transport blocka...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K47/36A61K47/22A61K31/4184A61K31/7048A61P33/10A61P33/14
CPCA61K9/146A61K9/145A61K31/4184A61K31/7048A61P33/10A61P33/14A61K2300/00
Inventor 蒋兴刚
Owner 四川乾通动物药业有限公司
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