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Portable diagnostic apparatus and the method thereof

A diagnostic device, portable technology, used in the field of systems for detecting analytes, capable of resolving discrepancies, misinterpretations, etc.

Pending Publication Date: 2021-04-09
SANWA BIOTECH LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Finally, in some models, the results are interpreted by the user, which can lead to discrepancies and even potential misunderstandings

Method used

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  • Portable diagnostic apparatus and the method thereof
  • Portable diagnostic apparatus and the method thereof
  • Portable diagnostic apparatus and the method thereof

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0119] 1. Equipment

[0120] figure 1 and figure 2 A diagnostic system is shown that includes (1) a diagnostic device 20 and (2) a microfluidic cartridge 22 that operates with the diagnostic device 20 . Microfluidic cartridge 22 containing microfluidic chip 24 and diagnostic chip 26 is configured to collect and manipulate at least one sample, which may contain at least one analyte. Microfluidic cartridge 22 also houses and / or holds at least one reagent. The diagnostic device 20 is a portable, hand-held and compact device comprising a control unit 28 , a microfluidic cartridge driver unit 30 , an optical inspection unit 32 and a display unit 34 . The control unit 28 controls and is connected to a microfluidic cartridge driver unit 30 , an optical inspection unit 32 and a display unit 34 . The microfluidic cartridge driver unit 30 is configured to accommodate and drive the microfluidic cartridge 22 such that collected samples and reagents pass through the microfluidic chip...

example 2

[0202] 2. Microfluidic cartridge

[0203] Such as Figure 6A , Figure 6B and Figure 6C The microfluidic cartridge 22 shown in FIG. 2 contains a diagnostic chip 26 affixed to a microfluidic chip 24 . In the embodiment shown it is smaller in size than a credit card and has a thickness of 1-10mm. The microfluidic chip 24 includes an electrical connection interface 78 for receiving control signals and power provided through the electrical connector 44 of the cartridge chamber 42 , a top portion 68 and a bottom portion 70 attached to the top portion 68 . In this example, top portion 68 and bottom portion 70 are assembled together by adhesive material or by a welding process. The bottom portion 70 may be made of an electrically insulating material such as plastic and resin materials. Such as Figure 6A As shown in , top portion 68 has a plurality of microgrooves 66, channel openings for fluid connection with microfluidic chip 24, and adhesive 74 for attaching microfluidic ch...

example 3

[0226] Test Methods

[0227] Another exemplary embodiment provides an on-site diagnostic method and operation of a diagnostic system. Reagents to facilitate analyte detection are preloaded into separate reservoirs 80 and sealed during the manufacturing process. Reagents held in at least one reservoir are selected from the group consisting of wash buffer (eg, PBS), blocking buffer (eg, bovine serum albumin (BSA)), lysis buffer (eg, PBS), Antigens, antibodies, and fluorophores (eg, fluorescein in PBS). In one embodiment, the wash buffer is PBS and the blocking buffer is PBS and BSA. In an exemplary embodiment, the microfluidic cartridge contains 5-12 reservoirs for holding reagents or samples. In some embodiments, the reagent volume is between 20-200ul. In some embodiments, the reagent volume is 50 uL. Reagents can be stored in one or more reservoirs. For example, if the capacity of one reservoir is insufficient to hold all required volumes of a particular reagent, additio...

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Abstract

A method and a portable diagnostic apparatus (20) for detecting at least one analyte from a sample using a microfluidic cartridge (22). The portable diagnostic apparatus (20) comprises a cartridge receiving unit, a cartridge driver unit (30) and an optical unit (32). A method and an apparatus of obtaining disease prevalence information comprising at least one of the portable diagnostic apparatus (20). A method and a system for managing a network of portable diagnostic apparatuses and obtaining disease prevalence information comprising at least one of the portable diagnostic apparatus (20). A diagnostic system with multiple automated features that is capable of providing a one-step solution to near-patient clinical evaluation and diagnosis.

Description

[0001] Cross References to Related Applications [0002] This application claims the benefit under 35 U.S.C. §119(e) of U.S. Provisional Application Serial No. 62722174, filed August 23, 2018, which is hereby incorporated by reference in its entirety. [0003] This application relates to PCT application number PCT / CN2015 / 0700567 filed on August 5, 2015, the contents of which are incorporated herein in its entirety by reference. technical field [0004] The present invention relates to a system for detecting an analyte and a method of use thereof. More specifically, the present invention relates to a microfluidic cartridge, a device for such a microfluidic cartridge. Background technique [0005] Traditional diagnosis, screening, disease staging, veterinary, drug testing, etc. are often performed in laboratories, and testing is often time consuming, expensive and requires many resources, supplies and support. Current systems require multiple steps between initial sample co...

Claims

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Application Information

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IPC IPC(8): A61B5/00G01N15/14
CPCA61B5/1455A61B5/1491A61B5/14546A61B5/0071A61B2560/0242A61B5/0022B01L2400/0677B01L2300/0883B01L2200/04B01L2300/161B01L2300/0887B01L2300/021B01L3/502715G01N33/54366G16H20/40G16H40/63Y02A90/10B01L2400/06G16H40/67B01L3/502746B01L7/00B01L2200/10B01L2300/0663B01L2300/1872G01N33/54386
Inventor 赵弘严惠霖伊萨贝莉·塞西尔·安吉拉·杜缇
Owner SANWA BIOTECH LTD
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