Ferrocene-berberine/indomethacin@glucose oxidase@hyaluronic acid nanomedicine, preparation method and application
A technology of glucose oxidase and indomethacin, applied in biochemical equipment and methods, oxidoreductase, drug combination and other directions, can solve problems such as limiting the further use of CDT, achieve easy reproducibility and characterization, good therapeutic effect, inhibiting transfer effect
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Embodiment 1
[0038] Embodiment 1 synthesis demethylberberine
[0039] Under conditions of solvent-free and vacuum and 190°C, 5g of berberine was placed in a 100mL clean round-bottomed flask and stirred for 45min, and the obtained berberine crude product was passed through column chromatography (elution machine volume ratio: chloroform / methanol=20 / 1) Demethylberberine (3.75 g, yield 79%) was isolated.
Embodiment 2
[0040] Embodiment 2 synthetic hydroxyethyl substituted berberine
[0041] With acetonitrile (20mL) as the solvent and potassium carbonate as the base (1.29g), place the demethylberberine (3g) prepared in Example 1 in a 100mL round-bottomed flask and stir for 25min, then add bromine in batches Ethanol (2.33g), continue reflux reaction 12h, remove reaction solvent and separate by column chromatography (elution machine volume ratio: chloroform / methanol=20 / 1), obtain hydroxyethyl berberine (3.53g, yield 85% ).
Embodiment 3
[0042] The hydroxyethyl berberine of embodiment 3 synthetic reduction
[0043] Under the condition of methanol (20mL) as solvent, the hydroxyethylberberine (2g, 4.49 mmol) prepared in Example 2 was placed in a 250mL round bottom flask and stirred, then sodium borohydride (0.34g, 8.98 mmol), continue to react for 12h, remove the reaction solvent and separate by column chromatography (elution machine volume ratio: chloroform / methanol=30 / 1) to obtain reduced hydroxyethylberberine (1.54g, yield 93%).
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