Method and system for continuously exciting crystallization

Abstract

The invention discloses a method and system for continuously exciting crystallization. The method comprises the following steps of controlling a laser generator to emit laser, and refracting and focusing the laser at a specified position of a test tube, averaging the radius of the bubbles of the plurality of image frames acquired at the same moment in two directions to obtain the average radius of the bubbles at the moment, calculating the average radius of each frame of image from bubble generation to disappearance, obtaining an array of the average radius of the bubbles corresponding to time, and fitting to obtain a function r=f(t) of the average radius of the bubbles and the time, controlling a plurality of laser generators to emit at intervals or circularly emit at intervals for continuous excitation, the continuous excitation being that when the moment tx meets f(tx-tx-1)=R, the laser generators are controlled to emit, and R is smaller than the maximum radius of bubble diffusion and is greater than the product of the system interval excitation duration and the bubble diffusion speed. According to the method and the system, a plurality of lasers are fed back and controlled to continuously excite in sequence after high-speed visual capture and fitting, and a gradually increased supersaturation gradient is locally formed in the solution, so that the discovery of a new crystal form is facilitated.

Description

Technical field[0001]The present invention relates to crystallization experiments, and more particularly to a method and system for continuous excitation crystals.Background technique[0002]An important goal of the crystalline experimental study is to study the polymorph behavior of the target, such as a compound molecule, and under different experimental conditions, different crystalline forms can be obtained. Get different crystalline forms as much as possible, study the physical, chemical nature, and the transformation relationship between these crystal forms, which have a very important role in industrial production and commercialization of the target.[0003]Currently, conventional crystalline experimental equipment is mainly controlled for different solvent environments, different temperatures, different cooling vents, and different agitation rates.[0004]A laser is a crystalline environment that can effectively create a topic supernaturation surgery, thereby obtaining more conven...

AI Technical Summary

Problems solved by technology

However, it takes a short time to form supersaturation by directly using laser for single-point excitation, and it is impossible to create the conditions for the continuous increase of supersaturation. Therefore, it is still difficult to use laser to discover new crystal forms.

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