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A method and system for in-depth analysis of traditional Chinese medicine network pharmacology

A technology of network pharmacology and analysis method, applied in the field of in-depth analysis of traditional Chinese medicine network pharmacology, can solve problems such as poor operability and poor accuracy, and achieve the effects of improved accuracy rate, accurate pathway sorting, and accelerated popularization and application

Active Publication Date: 2022-05-03
TIANJIN UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0008] Therefore, for traditional Chinese medicine, especially compound Chinese medicine, the current method enriches many pathways, has poor accuracy and poor operability, and more effective methods are still needed

Method used

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  • A method and system for in-depth analysis of traditional Chinese medicine network pharmacology
  • A method and system for in-depth analysis of traditional Chinese medicine network pharmacology
  • A method and system for in-depth analysis of traditional Chinese medicine network pharmacology

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Embodiment 1

[0046] 1. Experimental materials

[0047] 1.1 Collection of disease-related targets

[0048] Utilize OMIM database (https: / / omim.org), DrugBank database (https: / / go.drugbank.com / ), Genecards database (https: / / www.genecards.org / ) to search for oral ulcer-related targets, and screen The keyword was set to "Oral ulcer", and duplicate targets retrieved from different databases were screened out.

[0049] 1.2 Collection of related targets of Yatongting Dropping Pills

[0050] Use the TCMSP database (https: / / tcmspw.com / tcmsp.php) to search for the target information of the main active ingredients of Yatong Tingdrop Pills, and use "clove", "piper longum" and "borneol" as keywords to search, The oral bioavailability (OB) is greater than or equal to 30%, and the drug like index (DL) is greater than or equal to 0.18 as screening parameters, and the ingredients with biological activity and pharmacological effects reported in relevant literature are also included , to retrieve the corr...

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Abstract

The invention discloses a method and system for in-depth analysis of traditional Chinese medicine network pharmacology. The method comprises the following steps: obtaining data on disease and Chinese medicine-related targets; constructing PPI networks for diseases and Chinese medicine components respectively, and performing intersection operations to obtain a network of traditional Chinese medicine intervening in diseases; Analyze the topological features of the network to obtain the core targets; perform biological function annotation and KEGG pathway analysis on the core targets; normalize the degree value of the core nodes of the network, and enrich according to the core target pathways In each link of the influence, develop the method of calculating the importance value tsig of the pathway t, sort according to the importance value tsig of the pathway t, rebuild the network for the upstream and downstream of the target on the important pathway and the influence effect, and finally select the enrichment to influence the pathway. The target of disease-related effect is used as the target of traditional Chinese medicine to intervene in disease. The pathways enriched by the method of the present invention are more accurate, concentrated, and highly operable, and provide a more scientific, objective, and quick analysis method and system for the interpretation of the mechanism of action of traditional Chinese medicine.

Description

technical field [0001] The invention relates to the technical field of biological information, in particular to a method and system for in-depth analysis of network pharmacology of traditional Chinese medicine. Background technique [0002] Traditional Chinese medicine and compound Chinese medicine play a role in treating diseases through the synergistic effect of multiple components and multiple targets. Although the curative effect is significant, there are many active ingredients in traditional Chinese medicine, the interaction with the body is complicated, and the mechanism of action is unclear, which has become a bottleneck for the modernization of Chinese medicine and the wide application of Chinese medicine . At present, there are many methods for studying the mechanism of action of traditional Chinese medicine and compound Chinese medicine, which generally include three research modes: chemical research, target research and systems biology. Although these methods ha...

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G16B40/00G16B50/10G16B20/00G16B25/20G16B15/30
CPCG16B40/00G16B50/10G16B20/00G16B25/20G16B15/30
Inventor 杨珍张艳军庄朋伟郭虹
Owner TIANJIN UNIV OF TRADITIONAL CHINESE MEDICINE