Preparation process and quality control method of Eleutherococcus senticosus reference extract

A quality control method and preparation technology, applied in the direction of measuring devices, instruments, scientific instruments, etc., can solve the problems of ineffective quality control and complicated medicinal ingredients

Pending Publication Date: 2021-05-07
SICHUAN NEO GREEN PHARMA TECH DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this patent is only for the determination of the content of its medicinal ingredient syringin. Due to the complexity of the medicinal components of the control extract of Acantho

Method used

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  • Preparation process and quality control method of Eleutherococcus senticosus reference extract
  • Preparation process and quality control method of Eleutherococcus senticosus reference extract
  • Preparation process and quality control method of Eleutherococcus senticosus reference extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0068] This example proposes the preparation process of the control extract of Acanthopanax senticosus.

[0069] Take 100g of Acanthopanax decoction pieces, add water to decoct twice, add 10 times the water for the first decoction, soak for 30 minutes, boil, keep boiling for 60 minutes, filter through a 200-mesh sieve, and immediately cool to room temperature; add 8 times for the second decoction Water, boiled, kept at a slight boil and decocted for 40 minutes, filtered through a 200-mesh sieve, combined with the water decoction, immediately cooled to room temperature, vacuum freeze-dried, subpackaged, and obtained.

[0070] The following study on the preparation process of Acanthopanax control extract.

[0071] 1. Experimental instruments and equipment

[0072] Electronic balance: JY series hundredth balance of Shanghai Fangrui Instrument Co., Ltd.;

[0073] Decoction pot: Delicious family automatic split ceramic decoction pot 4 liters;

[0074] Sieve: Jiufeng sieve 200 me...

Embodiment 2

[0106] This example relates to the preparation of 18 batches of Acanthopanax control extracts.

[0107] 1. source

[0108] According to the requirements of "Technical Requirements for Quality Control and Standard Formulation of Traditional Chinese Medicine Formula Granules (Draft for Comment)", a total of 18 batches of Acanthopanax senticosus from Jixi City, Heilongjiang, Linkou County, Jilin and other production areas were collected, as shown in Table 4 below. It meets the requirements of the 2015 edition of the Chinese Pharmacopoeia.

[0109] Table 4 Summary of test results

[0110]

[0111]

[0112] 2. Concocted

[0113] The above 18 batches of Acanthopanax senticosus were processed in accordance with the "General Principles of Quality Standards for Herbal Pieces (Trial)" and "Chinese Pharmacopoeia" 2015 Edition, Part I Acanthopanax [Processing].

[0114] The specific method is: remove impurities, wash, soak for a while, moisten thoroughly, cut into thick slices, a...

Embodiment 3

[0142] This example is a quality control method for the reference extract of Acanthopanax senticosus. Of course, this quality control method can also be applied to the quality control of Acanthopanax senticosus formula granules or its single Chinese medicine preparation.

[0143] 1. Experimental instruments and materials

[0144] High performance liquid chromatography: Agilent 1260 high performance liquid chromatography, Waters e2695 high performance liquid chromatography, Shimadzu LC-20AD high performance liquid chromatography;

[0145] Electronic balance: ME204E / 02, MS205DU, XP26 (Mettler-Toledo Instrument Co., Ltd.);

[0146] Ultrapure water machine: cell type 1810A (Shanghai Mole Scientific Instrument Co., Ltd.);

[0147] Ultrasonic cleaner: KQ-600DB type (600W, 40KHz; Kunshan Ultrasonic Instrument Co., Ltd.);

[0148] Chromatographic column: ZORBAX Eclipse Plus C18 Analytical 4.6×250mm 5-Micron, ZORBAX Eclipse XDB C18 Analytical 4.6×250mm 5-Micron, Kromasil 100-5-C18 4....

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Abstract

The invention discloses a preparation process and a quality control method of an Eleutherococcus senticosus reference extract, the Eleutherococcus senticosus reference extract is prepared by decocting and extracting Eleutherococcus senticosus decoction pieces as a raw material, in the preparation process, the powder yield and the content of syringin which is an effective substance can be effectively controlled by reasonably controlling the decoction times, the water addition amount, the decoction time and the like, the stability of the radix acanthopanacis senticosi reference extract component is ensured, and the process is stable in operation. The quality control method can realize the stability and reliability of the preparation process of the Eleutherococcus senticosus reference extract.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine preparations and detection, and in particular relates to a preparation process and a quality control method of acanthopanax control extract. Background technique [0002] With the research and development of modern Chinese medicine preparations, the inconvenience and uncertainty in the efficacy of traditional decoction methods have become more and more prominent, and have greatly affected and restricted the application and promotion of Chinese medicine preparations in the market. In order to maximize drug efficacy, reduce toxic and side effects, and meet the clinical requirements of traditional Chinese medicine, it is the key to improve the extraction process of traditional Chinese medicine preparations and establish exclusive quality control. [0003] Acanthopanax is the dry root and rhizome or stem of the shrub plant Acanthopanax senticosus (Rupr. et Maxim.) Harms of the family Aralia...

Claims

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Application Information

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IPC IPC(8): G01N30/86G01N30/06
CPCG01N30/8686G01N30/06
Inventor 周厚成胡昌江钟磊刘珂汪席敏张开元
Owner SICHUAN NEO GREEN PHARMA TECH DEV
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