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Nano resveratrol-coated compound as well as preparation method and application thereof

A technology of resveratrol and complexes, applied in the field of nanometers, can solve the problems of unsafe use, adverse effects, and toxicity of polyethylene glycol compounds, and achieve the effects of improving bioavailability, stable quality, and high biological activity

Pending Publication Date: 2021-05-11
JIANGXI SCI & TECH NORMAL UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, it has been reported that the use of polyethylene glycol and its derivatives in cosmetics will have certain risks and adverse effects
Polyethylene glycol can cause irritation and systemic toxicity when used on broken skin, and industry groups reviewing the safety of cosmetic ingredients have concluded that some polyethylene glycol compounds are unsafe for use on damaged skin (although evaluations generally recognize these use of chemicals in cosmetics)

Method used

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  • Nano resveratrol-coated compound as well as preparation method and application thereof
  • Nano resveratrol-coated compound as well as preparation method and application thereof
  • Nano resveratrol-coated compound as well as preparation method and application thereof

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preparation example Construction

[0025] The invention provides a method for preparing a nano-encapsulated resveratrol complex, comprising the following steps:

[0026] (1) mixing the lecithin solution and the resveratrol solution to obtain the first mixed solution;

[0027] (2) adding the first mixed solution to water to obtain the second mixed solution;

[0028] (3) After the second mixed solution is purified, the nano-encapsulated resveratrol complex can be obtained.

[0029] When the present invention prepares the nano-encapsulated resveratrol complex, the lecithin solution and the resveratrol solution are firstly mixed to obtain the first mixed solution.

[0030] In the present invention, both the lecithin solution and the resveratrol solution are solubilized by dimethyl sulfoxide.

[0031] In the present invention, the concentration of the lecithin solution is preferably 10-40 mg / mL, more preferably 20 mg / mL; the concentration of the resveratrol solution is preferably 10-40 mg / mL, more preferably 20 mg...

Embodiment 1

[0046] (1) 100 mg lecithin was dissolved in 10 mL of DMSO to obtain a 10 mg / mL lecithin solution; 100 mg resveratrol was dissolved in 10 mL of DMSO to obtain a 10 mg / mL resveratrol solution;

[0047] (2) Mix 25 μL lecithin solution and 20 μL resveratrol solution to obtain the first mixed solution;

[0048] (3) In the second container, 5 mL of purified water was stirred at 3000 rpm;

[0049] (4) adding the first mixed solution dropwise to the stirred purified water to obtain the second mixed solution;

[0050] (5) Purify the second mixed solution with AmiconFilter (100KDa) to remove DMSO and unencapsulated RSV. The solution is centrifuged at 3000 rpm for 7 minutes and washed intermittently to remove all organic compounds in the nanoparticles. solvent, and after centrifugation, collect the residue to obtain the nano-encapsulated resveratrol complex, that is, resveratrol nanoparticles.

Embodiment 2

[0052](1) 200mg lecithin was dissolved in 10mL of DMSO to obtain a 20mg / mL lecithin solution; 200mg resveratrol was dissolved in 10mL of DMSO to obtain a 20mg / mL resveratrol solution;

[0053] (2) Mix 25 μL lecithin and 20 μL resveratrol to obtain the first mixed solution;

[0054] (3) In the second container, 5 mL of purified water was stirred at 2000 rpm;

[0055] (4) adding the first mixed solution dropwise to the stirred purified water to obtain the second mixed solution;

[0056] (5) Purify the second mixed solution with AmiconFilter (100KDa) to remove DMSO and unencapsulated RSV. The solution is centrifuged at 2000 rpm for 7 minutes and washed intermittently to remove all organic compounds in the nanoparticles. solvent, and after centrifugation, the remaining LC (RSV) was collected to obtain the nano-encapsulated resveratrol complex, that is, resveratrol nanoparticles.

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Abstract

The invention belongs to the field of a nanotechnology, and provides a nano resveratrol-coated compound as well as a preparation method and application thereof. The preparation method of the nano resveratrol-coated compound comprises the following steps of (1) mixing a lecithin solution and a resveratrol solution to obtain a first mixed solution; (2) adding the first mixed solution into water to obtain a second mixed solution; and (3) purifying the second mixed solution to obtain the nano resveratrol-coated compound. After resveratrol coats lecithin nanoparticles, the effect of continuously and slowly releasing antioxidant components and the good effect of promoting transdermal permeation of antioxidants are achieved, the residence time of the resveratrol in the acting skin part is prolonged, and the bioavailability of the resveratrol is improved.

Description

technical field [0001] The invention relates to the field of nanotechnology, in particular to a nano-encapsulated resveratrol compound and its preparation method and application. Background technique [0002] Resveratrol (RSV), also known as stilberol, is a natural polyphenolic flavonoid compound that can be found in the seeds and skins of grapes (red wine), mulberries, peanuts, rhubarb, etc. Resveratrol It has anti-oxidation and anti-free radical effects. Resveratrol contains cis and trans isomers, the latter being considered to be biologically active and most abundant. Resveratrol as a natural antioxidant, the most prominent role is to scavenge free radicals or inhibit the formation of free radicals, delay the aging process of skin cells, inhibit lipid peroxidation and inhibit the activity of tyrosinase, and reduce the formation of melanin , to achieve whitening, blemish, moisturizing and other skin care effects. After intravenous administration, resveratrol is rapidly ...

Claims

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Application Information

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IPC IPC(8): A61K8/34A61K8/55A61K8/11A61Q19/08A61Q19/02A61Q19/00
CPCA61K8/347A61K8/553A61K8/11A61Q19/08A61Q19/02A61Q19/00A61K2800/56A61K2800/782A61K2800/413
Inventor 陈雯廖文波
Owner JIANGXI SCI & TECH NORMAL UNIV
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