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Carbidopa-levodopa sustained-release tablet and preparation method thereof

A technology for sustained-release tablets and levodopa, which is applied in the field of medicine, can solve the problems of difficult production process, difficult industrialized production and the like, and achieves the effects of good color, easy industrialized production, and alleviation of adverse reactions in the surrounding area.

Inactive Publication Date: 2021-05-11
浙江美华鼎昌医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Therefore, the existing carlevodopa controlled-release tablets have the problems that the production process is difficult and not easy for industrialized production.

Method used

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  • Carbidopa-levodopa sustained-release tablet and preparation method thereof
  • Carbidopa-levodopa sustained-release tablet and preparation method thereof
  • Carbidopa-levodopa sustained-release tablet and preparation method thereof

Examples

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preparation example Construction

[0051] The preparation method of carlevodopa slow-release tablet, comprises the following steps,

[0052] (1) mixing,

[0053] The carbidopa, levodopa and slow-release material that take prescription quantity are mixed homogeneously;

[0054] (2) Adhesive preparation,

[0055] Weigh the prescribed amount of adhesive, add an appropriate amount of water and / or ethanol, stir to form a solution, and set aside;

[0056] (3) Granulation,

[0057] Put the mixed powder prepared in the step (1) in the wet granulator, add the coloring agent of the prescribed amount into the wet granulator, and then add the solution in the step (2), and flow it after the addition of the solution is completed. Fluidized bed drying, control the drying temperature in the fluidized bed at 40°C to 80°C, until the moisture in the material is below 4%, take it out for later use;

[0058] (4) Tablets,

[0059] The granules prepared in the step (3) are added with a prescribed amount of lubricant, and then co...

Embodiment 1

[0062] Prescription composition (dosage per 1000 tablets, unit: g)

[0063] Raw materials Dosage (g) carbidopa 54.0 Levodopa 200.0 Hydroxypropyl Methyl Cellulose Solution 1 Hydroxypropyl Cellulose 20.0 Yellow Iron Oxide 1.0 Magnesium stearate 3.0 Co-made 1000 pieces

[0064] Weigh hydroxypropyl methylcellulose according to the prescription amount, add appropriate amount of hot water to make it swell, add purified water after cooling to make a solution for later use; weigh the prescription amount of carbidopa, levodopa, and hydroxypropyl cellulose Mix evenly, add yellow iron oxide and the above-mentioned binder for wet granulation machine granulation, fluidized bed drying, add additional magnesium stearate, mix evenly, and tablet with a conventional tablet machine.

Embodiment 2

[0066] Prescription composition (dosage per 1000 tablets, unit: g)

[0067]

[0068]

[0069] Weigh hydroxypropyl methylcellulose according to the prescription amount, add appropriate amount of hot water to make it swell, add purified water after cooling to make a solution for later use; weigh the prescription amount of carbidopa, levodopa, and hydroxypropyl cellulose Mix evenly, add yellow iron oxide and the above-mentioned binder for wet granulation machine granulation, fluidized bed drying, add additional magnesium stearate, mix evenly, and tablet with a conventional tablet machine.

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Abstract

The invention relates to the technical field of medicines, and particularly discloses a carbidopa-levodopa sustained-release tablet and a preparation method thereof. The carbidopa-levodopa sustained-release tablet comprises the following components in parts by weight of 8-20 parts of carbidopa, 35-75 parts of levodopa, 1-6 parts of a sustained-release material, 0.5-2 parts of an adhesive, 0-1.5 parts of a lubricant and 0-1 part of a coloring agent. The carbidopa-levodopa sustained-release tablet has the characteristics that the release of carbidopa and levodopa can be better controlled, the treatment effect is relatively good, the production process is simple, and the industrial production is easy.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a carlevodopa sustained-release tablet and a preparation method thereof. Background technique [0002] Parkinson's disease (Parkinsonism disease, PD), also known as "parkinsonism", is one of the most common neurological diseases, mainly due to the degeneration of the substantia nigra-striatum system in the brain, resulting in a lack of dopamine content, which leads to cone In vitro system dysfunction. [0003] Levodopa is the precursor of dopamine, which enters the central nervous system through the blood-cerebrospinal fluid barrier, and is converted into dopamine by decarboxylase, thereby improving the symptoms of Parkinson's disease such as rigidity, slow movement, balance disturbance and tremor. When levodopa is administered orally, it is rapidly decarboxylated to dopamine in extracerebral tissues, so that only a small fraction of the administered dose is transported unchang...

Claims

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Application Information

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IPC IPC(8): A61K31/198A61K9/20A61K47/38A61K47/32A61K47/12A61K47/04A61P25/16
CPCA61K31/198A61K9/2054A61K9/2027A61K9/2013A61K9/2009A61K9/2095A61P25/16A61K2300/00
Inventor 王立康李黄强王传跃
Owner 浙江美华鼎昌医药科技有限公司
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