A kind of anti-tigit monoclonal antibody and application thereof

A monoclonal antibody and variant technology, applied in the direction of antibodies, applications, anti-inflammatory agents, etc., to achieve a wide range of application prospects and the effect of relieving immunosuppression
CN112794909BActive Publication Date: 2022-06-14EXCELMAB INC
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Patent Information

Authority / Receiving Office
CN Β· China
Patent Type
Patents(China)
Current Assignee / Owner
EXCELMAB INC
Publication Date
2022-06-14

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Abstract

The present invention provides an anti-TIGIT monoclonal antibody and application thereof, the anti-TIGIT monoclonal antibody comprises a heavy chain variable region and a light chain variable region; the heavy chain variable region comprises SEQ ID NO:1 The heavy chain CDR1, the heavy chain CDR2 shown in SEQ ID NO:2 and the heavy chain CDR3 shown in SEQ ID NO:3; the light chain variable region includes the light chain CDR1 shown in SEQ ID NO:4, SEQ ID NO:4 Light chain CDR2 shown in ID NO:5 and light chain CDR3 shown in SEQ ID NO:6. The anti-TIGIT monoclonal antibody of the invention has strong specific recognition and binding ability to the antigen TIGIT, can effectively block the combination of TIGIT and its ligand CD155, and has broad application prospects.
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Description

technical field

[0001] The invention belongs to the technical field of antibody engineering, and relates to an anti-TIGIT monoclonal antibody and its application. Background technique

[0002] T cell immunoglobulin and ITIM domain (TIGIT) is a member of the poliovirus receptor (PVR) / Nectin family, composed of extracellular immunoglobulin variable region (IgV) domain, type I transmembrane domain, Composed of the intracellular domain of the classical immunoreceptor tyrosine inhibitory motif (ITIM) and the immunoglobulin tyrosine tail (ITT) motif, it is a co-inhibitory receptor expressed in lymphocytes and plays a role in effector and regulation It is highly expressed in sex CD4+ T cells, follicular helper CD4+ T cells, effector CD8+ T cells and natural killer (NK) cells, and has become an emerging target for cancer immunotherapy.

[0003] Currently, several mechanisms for TIGIT-mediated suppression of effector T cells and NK cells have been proposed. TIGIT may act as a ligan...

Claims

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