Biomarker for early detection of severe hepatitis B virus as well as detection kit and application thereof

A technology for biomarkers and early detection, applied in the field of biomarkers and detection kits for early detection of severe hepatitis B virus
CN112795643APending Publication Date: 2021-05-14SHANDONG UNIV
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Patent Information

Authority / Receiving Office
CN Β· China
Patent Type
Applications(China)
Current Assignee / Owner
SHANDONG UNIV
Publication Date
2021-05-14

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Abstract

The invention relates to the technical field of biomedicine, in particular to a biomarker for early detection of severe hepatitis B virus as well as a detection kit and application thereof. The invention provides a biomarker for early detection of severe hepatitis B virus. The sequence of the biomarker is as shown in SEQ ID NO. 1. The invention further provides application of the biomarker in preparation of a kit for early detection of the severe hepatitis B virus and the kit for early detection of the severe hepatitis B. The kit comprises a primer pair and a probe for specific detection of GSTP1 methylation, the primer pair and the probe are used for detecting the reference gene ALU-C4. The detection method disclosed by the invention can be used for detecting trace DNA in peripheral blood of a human body, is high in sensitivity and strong in specificity, and is widely applied to detection of specimens with low DNA content and high loss rate.
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Description

technical field

[0001] The invention relates to the technical field of biomedicine, in particular to a biomarker for early detection of severe hepatitis B virus, a detection kit and application thereof. Background technique

[0002] Severe hepatitis is a serious liver disease characterized by a large number of liver cell necrosis on the basis of chronic liver disease or cirrhosis. Its main manifestations are jaundice, coagulation dysfunction, hepatic encephalopathy and ascites, etc., with a high incidence of complications , is one of the leading causes of death in patients with liver disease. my country is a high prevalence area of ​​hepatitis B, and hepatitis B virus infection is the main cause of severe hepatitis in my country. Severe hepatitis B is in a dangerous condition, with poor prognosis and high fatality rate. At present, there is no effective method and means to evaluate the effect of clinical treatment in clinical practice. Therefore, there is an urgent need t...

Claims

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