Biomarker and detection kit for early detection of severe hepatitis B virus, and application ofbiomarker

A biomarker and early detection technology, which is applied in the field of early detection of severe hepatitis B virus biomarkers and its detection kit, can solve the problems of reduced antioxidant capacity, reduced expression of GSTM3, and aggravated oxidative damage, so as to reduce related deaths rate effect
CN112725542APending Publication Date: 2021-04-30SHANDONG UNIV
3 Cites 0 Cited by

Patent Information

Authority / Receiving Office
CN Β· China
Patent Type
Applications(China)
Current Assignee / Owner
SHANDONG UNIV
Publication Date
2021-04-30

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention relates to the technical field of biomedicine, particularly to a biomarker and a detection kit for early detection of severe hepatitis B virus, and application of the biomarker. The invention provides a biomarker for early detection of severe hepatitis B virus, wherein the sequence of the biomarker is shown as SEQ ID NO. 1. The invention also provides an application of the biomarker in preparation of a kit for early detection of severe hepatitis B virus, and a kit for early detection of severe hepatitis B. The kit comprises a primer pair and a probe for specific detection of GSTM3 methylation, and a primer pair and a probe for detecting a reference gene ALU-C4. The detection method disclosed by the invention can be used for detecting an extremely small amount of DNA in peripheral blood of a human body, is high in sensitivity and strong in specificity, and is widely applied to detection of specimens with low DNA content and high loss rate.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The invention relates to the technical field of biomedicine, in particular to a biomarker for early detection of severe hepatitis B virus, a detection kit and application thereof. Background technique

[0002] Severe hepatitis is a serious liver disease characterized by a large number of liver cell necrosis on the basis of chronic liver disease or cirrhosis. Its main manifestations are jaundice, coagulation dysfunction, hepatic encephalopathy and ascites, etc., with a high incidence of complications , is one of the leading causes of death in patients with liver disease. my country is a high prevalence area of ​​hepatitis B, and hepatitis B virus infection is the main cause of severe hepatitis in my country. Severe hepatitis B is in a dangerous condition, with poor prognosis and high fatality rate. At present, there is no effective method and means to evaluate the effect of clinical treatment in clinical practice. Therefore, there is an urgent need t...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More