A kind of methoxyaniline compound and synthetic method thereof
A technology of methoxyaniline and nitro compounds, which is applied in the field of methoxyaniline compounds and their synthesis, can solve the problems of complex synthesis steps, poor atom economy, and large functional group compatibility limitations, and achieve group positioning and selection Good performance, shortened reaction steps, and shortened production cycle
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Embodiment 1-16
[0028] Step 1: the nitro compound (see Table 1 for specific materials) and methanol are added to the reaction vessel, and respectively reducing agent (see Table 1 for specific materials), photocatalyst (see Table 1 for specific materials), water (see Table for specific feeding amounts) 1), organic acid (refer to Table 1 for specific substances), and organic solvent (refer to Table 1 for concrete substances) are added to the reaction vessel.
[0029] Step 2: the reaction vessel is uniformly heated (such as oil bath heating) to the temperature described in Table 1 and irradiated under blue light, and the nitro compound and methanol are reacted in a solvent for the time described in Table 1; It should be noted that argon protection is selected for this reaction atmosphere.
[0030] Step 3: Purification step.
[0031] Table 1: Molar ratio and reaction temperature of nitro compounds to methanol, reducing agent, photocatalyst, water, organic organic acid, organic solvent (nitro com...
Embodiment 11
[0035] The nuclear magnetic data of the product of Example 11 are as follows:
[0036] 1 H NMR (400MHz, Chloroform-d) δ6.91-6.88(m, 2H), 6.58(d, J=7.9Hz, 1H), 3.84(s, 3H), 3.78(br, 2H); 13 C NMR (100MHz, Chloroform-d) δ147.8, 135.2, 123.6, 115.7, 113.7, 109.5, 55.6.
Embodiment 12
[0037] The nuclear magnetic data of the product of Example 12 are as follows:
[0038] 1 H NMR (400MHz, DMSO-d 6 )δ6.96(d,J=2.5Hz,1H),6.77-6.71(m,3H),4.84(br,2H),3.64(s,4H); 13 C NMR (100MHz, Chloroform-d) δ152.7, 137.7, 117.4, 116.7, 115.0, 109.6, 55.9.
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