Method for detecting briracetam and an isomer thereof

A detection method and isomer technology, applied in the field of analytical chemistry, can solve problems such as flipping, and achieve the effects of good specificity and repeatability, high sensitivity, and accurate and reliable inspection results

Pending Publication Date: 2021-05-25
HANGZHOU HEZE PHARMA TECH +1
View PDF6 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] This compound has two chiral centers, and under conditions such as high temperature or light, it may cause the inversion of the chiral centers, thereby introducing three isomer impurities

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Method for detecting briracetam and an isomer thereof
  • Method for detecting briracetam and an isomer thereof
  • Method for detecting briracetam and an isomer thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0036] Hereinafter, preferred embodiments of the present invention will be described in detail with reference to the accompanying drawings. The experimental methods not indicating specific conditions in the preferred embodiments are generally in accordance with conventional conditions, and the given examples are to better illustrate the content of the present invention, but the content of the present invention is not limited to the given examples. Therefore, non-essential improvements and adjustments to the implementation by those skilled in the art based on the content of the invention above still fall within the protection scope of the present invention.

[0037] Test 1:

[0038] Instrument: Diane U3000

[0039] Chromatographic column: Chiralpak AD-H, 4.6mm×250mm, 5μm or a column with equivalent performance

[0040] Mobile phase: n-hexane-isopropanol (90:10)

[0041] Flow rate: 1.0ml / min

[0042] Column temperature: 20°C

[0043] Detector: UV

[0044] Detection wavelen...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
wavelengthaaaaaaaaaa
wavelengthaaaaaaaaaa
separationaaaaaaaaaa
Login to view more

Abstract

The invention relates to a method for detecting briracetam and an isomer thereof, which comprises a step of detecting by adopting a high performance liquid chromatography, and the liquid chromatography conditions are as follows: silica gel coated with amylose-tri (3, 5-dimethylphenyl carbamate) on the surface is used as a filling agent; and a mixed solution of n-hexane, isopropanol and organic base is used as a mobile phase, and the mobile phase enters a detector for detection. The method can effectively separate and measure the contents of the enantiomers and diastereoisomers of the briracetam, is simple and convenient to operate, high in sensitivity, good in specificity and repeatability, accurate and reliable in detection result, and has very important significance for realizing quality control of the briracetam and preparations thereof, and the solvent peak does not interfere with the measurement in the detection process.

Description

technical field [0001] The invention belongs to the field of analytical chemistry, and in particular relates to a detection method for brivaracetam and its isomers. Background technique [0002] The molecular formula of Brivaracetam is C11H20N2O2, the English name is Brivaracetam, the CAS number is 357336-20-0, and the structural formula is shown in Formula IV. It is a second-generation antiepileptic drug developed by UCB Company in Belgium, and its trade name is Briviact®. For the treatment of partial-onset epilepsy patients 16 years of age and older, adjuvant therapy with or without secondary generalized seizures. [0003] [0004] Formula Ⅳ: Briracetam [0005] The compound has two chiral centers, which may cause inversion of the chiral centers under conditions such as high temperature or light, thereby introducing three isomer impurities. Since the main active ingredient that works is brivaracetam, and the increase in the content of isomer impurities will reduce the...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/88
CPCG01N30/88G01N2030/884
Inventor 倪晟夏金强叶艳蓉王菲周亮赵航徐兵勇陈鸿翔姜维斌屠芳芳卜华荣戴寿沣汤丽玲
Owner HANGZHOU HEZE PHARMA TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap