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Preparation method and application of synthesized nicotine salt

A technology of nicotine salt and nicotine, which is applied in the field of synthetic nicotine salt preparation, can solve the problems of increasing the irritation of nicotine salt, bad smoking experience, and reducing alkalinity, so as to improve smoking experience, good smoking experience, and reduce irritation Effect

Active Publication Date: 2021-05-28
SHENZHEN IPURE BIO-TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Free nicotine has a higher alkalinity, which increases during the reaction, which can lead to a more severe sore throat
Organic acids have the opposite effect, which can reduce the pH of nicotine, reduce the alkalinity in the reaction process, and improve the roar feeling. In the reaction process of synthetic nicotine and organic acid, the synthetic nicotine is volatile and prone to oxidation, which will not only reduce the synthetic nicotine Yield of nicotine salt, also easy to change color
Using benzoic acid to react with synthetic nicotine to prepare synthetic nicotine salt can effectively reduce the oxidation of synthetic nicotine, but it will also increase the irritation of nicotine salt, resulting in a bad smoking experience

Method used

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  • Preparation method and application of synthesized nicotine salt
  • Preparation method and application of synthesized nicotine salt
  • Preparation method and application of synthesized nicotine salt

Examples

Experimental program
Comparison scheme
Effect test

preparation example 1

[0042] Preparation examples 1-7 provide a kind of lactic acid fermented by lactic acid bacteria, and preparation example 1 is taken as an example for illustration below.

[0043] The lactic acid fermented by lactic acid bacteria provided by Preparation Example 1, its preparation steps are:

[0044] (1) Add the starch medium into the fermenter and stir for 15 minutes, and then add steam. When the steam pressure in the fermenter reaches 0.12MPa and the temperature reaches 120°C, stir for 40 minutes to sterilize the culture medium. After the sterilization is completed, Open the cooling valve to cool down to 18°C ​​and keep stirring, inoculate the lactic acid bacteria strains for expansion, after inspection meets the production requirements, the expanded lactic acid bacteria are obtained, and keep at 18°C ​​for use;

[0045] (2) 1kg corn starch, 2kg molasses, and 15kg deionized water are added to the raw material tank, stirred to a uniform state to obtain a raw material liquid, th...

Embodiment 1

[0061] Embodiments 1-17 provide a preparation method for synthesizing nicotine salt, which will be described below by taking Embodiment 1 as an example.

[0062] The synthetic nicotine salt preparation method that embodiment 1 provides, its steps are:

[0063] S1: First add 60g of 1,2-propanediol, then add 3.5g of benzoic acid, 2.5g of anhydrous citric acid, 6g of L-lactic acid (CAS No. 79-33-4), 5.5g of L-malic acid (CAS No. 97-67-6) and 17.5g (S)-3-(1-methylpyrrolidin-2-yl)pyridine were mixed to obtain a premix;

[0064] S2: The premix was sealed and stirred at 20°C for 8 hours, and left to stand for 24 hours to obtain a synthetic nicotine salt;

[0065] Wherein, the CAS number of (S)-3-(1-methylpyrrolidin-2-yl)pyridine is 54-11-5, purchased from Yunnan Chansong Technology Co., Ltd.

Embodiment 2-5

[0066] Examples 2-5 are the same as Example 1, except that the quality of the raw materials for the synthesis of nicotine salt is different, see Table 4 for details.

[0067] Table 4

[0068] components Example 1 Example 2 Example 3 Example 4 Example 5 1,2-propanediol 60g 60g 60g 60g 60g benzoic acid 3.5g 4.5g 4g 4g 4g anhydrous citric acid 2.5g 3.5g 3g 3g 3g L-lactic acid 6g 8g 7g 7g 7g L-malic acid 5.5g 6.5g 6g 6g 6g (S)-3-(1-Methylpyrrolidin-2-yl)pyridine 17.5g 22.5g 20g 16g 24g

[0069] Examples 6-7 are the same as Example 3, except that the process parameters for the synthesis of nicotine salt are different, see Table 5 for details.

[0070] table 5

[0071] Reaction parameters Example 3 Example 6 Example 7 temperature reflex 20℃ 30℃ 25℃ Stiring time 8h 6h 7h

[0072] Examples 8-14 are the same as Example 7, except that the L-lactic acid is replaced by ...

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Abstract

The invention relates to the field of electronic cigarette liquid, in particular to a preparation method and application of a synthesized nicotine salt The synthesized nicotine salt preparation method comprises the following steps: S1, firstly adding propylene glycol, then adding organic acid and synthetic nicotine, and mixing; and S2, sealing and stirring at 20-30 DEG C for 6-8 hours, and standing to obtain synthesized nicotine salt, wherein the mass ratio of the synthetic nicotine to the organic acid is (0.8-1.2):1, and the organic acid is a mixture of benzoic acid, anhydrous citric acid, lactic acid and malic acid. According to the preparation method of the synthesized nicotine salt, heating is not needed, volatilization of the synthetic nicotine is greatly reduced, and the smoking experience of the synthesized nicotine salt is improved.

Description

technical field [0001] The present application relates to the field of electronic cigarette oil, in particular to a preparation method and application of a synthetic nicotine salt. Background technique [0002] E-cigarettes are electronic products that mimic cigarettes and have the same look, smoke, taste and feel as cigarettes. It is a product that allows users to inhale after turning liquid nicotine salt into steam by means of atomization. Liquid nicotine salt e-liquid is the key to the quality of e-cigarette smoking. [0003] Nicotine salt e-liquid is used as a type of e-liquid for smoking addiction. Compared with traditional nicotine e-liquid extracted from tobacco, the content of synthetic nicotine salt is higher, which can be more easily inhaled by human blood, and can be easily relieved. The nicotine needs of nicotine addicts have a more comfortable inhalation and addiction relief ability. Appropriate use of low-power devices can achieve the advantages of fast addic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D401/04C07C63/08C07C59/08C07C59/265C07C59/245C07C51/41C12P7/56C12N1/20
CPCC07D401/04C07C63/08C07C59/08C07C59/265C07C59/245C07C51/412C12P7/56C12N1/20
Inventor 杨鹏苏磊卢帅刘巍俊王一骑唐泽龙
Owner SHENZHEN IPURE BIO-TECH CO LTD
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