Quartz crystal microbalance sensor, preparation method and application thereof

A technology of quartz crystal and microbalance, which is applied in the field of sensor detection, can solve the problems of shortened life and the influence of the electrode detection performance of QCM crystal oscillator, and achieve the effects of prolonging service life, good piezoelectric effect and good response relationship

Pending Publication Date: 2021-05-28
杭州诺蒙微晶生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the electrode is cleaned by soaking it in the cleaning solution, and many cleaning solutions are often corrosive, which will have a great impact on the electrode detection performance of the QCM crystal oscillator, and greatly shorten the service life.

Method used

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  • Quartz crystal microbalance sensor, preparation method and application thereof
  • Quartz crystal microbalance sensor, preparation method and application thereof

Examples

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preparation example Construction

[0034] Specifically, the preparation method of the quartz crystal microbalance sensor comprises the following steps:

[0035] Step 1, take by weighing the Zn(CH 3 COO) 2 2H 2 O and HO(CH 2 ) 2 NH 2 and dissolved in an equal amount of C 4 h 10 o 2 in, stir evenly to obtain HO(CH 2 ) 2 NH 2 solution with Zn(CH 3 COO) 2 2H 2 O solution;

[0036] Step 2, the Zn(CH 3 COO) 2 2H 2 O solution was slowly added to HO(CH 2 ) 2 NH 2 solution, stir evenly to obtain ZnO gel; then add polyethylene glycol to obtain ZnO solution, and static aging for later use;

[0037] Step 3, immerse the electrode of the crystal oscillator into the ZnO solution prepared in step 2 and take it out, repeat 2-3 times, dry, and anneal to obtain an electrode coated with ZnO seeds;

[0038] Step 4. Configure ZnNO 3 , (CH 2 ) 6 N 4 , a mixed solution of β-cyclodextrin, the electrode coated with ZnO seeds is immersed in the mixed solution to prepare an electrode coated with a ZnO nanocomposit...

Embodiment 1

[0047] A kind of quartz crystal microbalance sensor is provided in the present embodiment, it comprises: crystal oscillator, the electrode surface of this crystal oscillator is decorated with self-cleaning coating, and this self-cleaning coating is ZnO / TiO 2 nanocomposite film.

[0048] The preparation method of this quartz crystal microbalance sensor comprises the steps:

[0049] Step 1, weigh 0.05mol Zn(CH 3 COO) 2 2H 2 O and 0.05mol HO(CH 2 ) 2 NH 2 and dissolved in 50ulC 4 h 10 o 2 in, stir evenly to obtain HO(CH 2 ) 2 NH 2 solution with Zn(CH 3 COO) 2 2H 2 O solution; wherein, the stirring temperature is 60°C, and the stirring time is 30min;

[0050] Step 2, the Zn(CH 3 COO) 2 2H 2 O solution was slowly added to HO(CH 2 ) 2 NH 2 In the solution, stir evenly to obtain ZnO gel; then add 0.3g polyethylene glycol-400 to obtain ZnO solution, and static aging for later use; wherein, the stirring temperature is 60°C, the stirring time is 2h, and the static a...

Embodiment 2

[0056] The difference with the above-mentioned embodiment is that:

[0057] The preparation method of the quartz crystal microbalance sensor provided in this embodiment comprises the following steps:

[0058] Step 1, weigh 0.1mol Zn(CH 3 COO) 2 2H 2 O and 0.1mol HO(CH 2 ) 2 NH 2 and dissolved in 50ulC 4 h 10 o 2 in, stir evenly to obtain HO(CH 2 ) 2 NH 2 solution with Zn(CH 3 COO) 2 2H 2 O solution; wherein, the stirring temperature is 60°C, and the stirring time is 30min;

[0059] Step 2, the Zn(CH 3 COO) 2 2H 2 O solution was slowly added to HO(CH 2 ) 2 NH 2 In the solution, stir evenly to obtain a ZnO gel; then add 0.6g polyethylene glycol-400 to obtain a ZnO solution, which is statically aged for use; wherein, the stirring temperature is 60°C, the stirring time is 2h, and the static aging time is 24h;

[0060] Step 3. Immerse the electrode of the crystal oscillator into the ZnO solution prepared in step 2 and take it out, repeat 2-3 times, dry, the im...

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Abstract

The invention relates to a quartz crystal microbalance sensor, a preparation method and application thereof, the quartz crystal microbalance sensor comprises a crystal oscillator, the electrode surface of the crystal oscillator is modified with a self-cleaning coating, and the self-cleaning coating comprises a ZnO/TiO2 nano composite film. According to the technical scheme, ZnO gel is prepared through a sol-gel method and then reacts with beta-cyclodextrin to obtain a beta-cyclodextrin modified ZnO nano composite film, then the beta-cyclodextrin modified ZnO nano composite film is immersed into suspension liquid containing titanium dioxide P25 and then dried to obtain a ZnO/TiO2 nano composite film, the prepared ZnO/TiO2 nano composite film is modified on the electrode surface of the crystal oscillator, therefore, based on the characteristics of the ZnO/TiO2 nano composite film, the purpose of self-cleaning of the crystal oscillator electrode can be achieved without immersing the crystal oscillator electrode in a cleaning solution, and the service life of the crystal oscillator electrode can be effectively prolonged.

Description

technical field [0001] The invention relates to the technical field of sensor detection, in particular to a quartz crystal microbalance sensor, a preparation method and an application thereof. Background technique [0002] The determination of human protein is of great significance. The appearance of many diseases in the human body usually manifests as abnormal protein content in the human body. For example, when the human body suffers from liver and gallbladder diseases, human γ-globulin will increase significantly; while when the human body suffers from some severe diseases, it often shows a decrease in albumin and an increase in fibrinogen. Therefore, it is possible to judge whether the human body has lesions by detecting changes in the protein content of the human body. [0003] Quartz crystal microbalance is a sensor that uses the piezoelectric effect of quartz crystal to convert the mass change of the electrode surface into the frequency change of the electrical signa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N29/02G01N29/036
CPCG01N29/022G01N29/036G01N2291/014G01N2291/022G01N2291/02809
Inventor 司士辉张友干
Owner 杭州诺蒙微晶生物科技有限公司
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