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Preparation method of high-efficiency bone repair material

A high-efficiency technology for bone repair, applied in medical science, prosthesis, tissue regeneration, etc., can solve the problem of low efficiency of bone repair

Inactive Publication Date: 2018-08-24
赵建平
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The main technical problem to be solved by the present invention is that although the current common hydroxyapatite bone repair materials have good biocompatibility and chemical stability, as explants, the efficiency of bone repair is relatively low, and it takes a long time The defects of talent and bone compact combination provide a preparation method of high-efficiency bone repair materials

Method used

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  • Preparation method of high-efficiency bone repair material

Examples

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Effect test

example 1

[0021] Mix calcium chloride, barium chloride and deionized water at a mass ratio of 3:1:20 to obtain a mixed solution, then mix the mixed solution with ethylenediaminetetraacetic acid at a mass ratio of 15:1 and put it into an ultrasonic oscillator In the process, react with ultrasonic oscillation at a frequency of 25kHz for 1h to obtain a self-made complexing solution for subsequent use; mix anhydrous ethanol and phosphorus pentoxide in a mass ratio of 15:1 and add them to the reaction kettle, first at a speed of 200r / min Stir and mix for 20 minutes to obtain a mixed solution, then adjust the pH of the mixed solution to 9.0 with a mass fraction of 20% ammonia water to obtain a precursor solution; drop the spare self-made complex solution into the above precursor solution at a mass ratio of 1:3, and heat Under the microwave irradiation treatment with a power of 300W for 12h, after the treatment, it was placed at a temperature of 4°C and aged for 24h, and after the aging was com...

example 2

[0023] Mix calcium chloride, barium chloride and deionized water at a mass ratio of 3:1:20 to obtain a mixed solution, then mix the mixed solution with ethylenediaminetetraacetic acid at a mass ratio of 15:1 and put it into an ultrasonic oscillator In the process, react with ultrasonic oscillation at a frequency of 28kHz for 1h to obtain a self-made complexing solution for subsequent use; mix absolute ethanol and phosphorus pentoxide in a mass ratio of 15:1 and then add them to the reaction kettle, first at a speed of 250r / min Stir and mix for 25 minutes to obtain a mixed solution, then adjust the pH of the mixed solution to 9.3 with a mass fraction of 20% ammonia water to obtain a precursor solution; drop the spare self-made complex solution into the above precursor solution according to a mass ratio of 1:3, and heat at 65°C Under microwave irradiation with a power of 350W for 14h, after the treatment, place it at a temperature of 5°C for 26h, and filter and separate to obtain...

example 3

[0025]Mix calcium chloride, barium chloride and deionized water at a mass ratio of 3:1:20 to obtain a mixed solution, then mix the mixed solution with ethylenediaminetetraacetic acid at a mass ratio of 15:1 and put it into an ultrasonic oscillator In the process, react with ultrasonic oscillation at a frequency of 30kHz for 2h to obtain a self-made complexing solution for subsequent use; mix absolute ethanol and phosphorus pentoxide in a mass ratio of 15:1 and then add it to the reaction kettle, firstly at a speed of 300r / min Stir and mix for 30 minutes to obtain a mixed solution, and then adjust the pH of the mixed solution to 9.5 with a mass fraction of 20% ammonia water to obtain a precursor solution; drop the spare self-made complex solution into the above precursor solution at a mass ratio of 1:3, and heat at 70°C Under microwave irradiation with a power of 400W for 15h, after the treatment, place it at a temperature of 6°C and let it age for 30h. After the aging, filter a...

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Abstract

The invention relates to a preparation method of a high-efficiency bone repair material and belongs to the technical field of preparation of artificial medical materials. The preparation method in theinvention comprises the following steps: mixing calcium chloride and barium chloride serving as raw materials to obtain a mixed solution; carrying out an ultrasonic oscillating reaction of the mixedsolution and EDTA (Ethylene Diamine Tetraacetic Acid) to produce self-made complexing liquor; carrying out a reaction of absolute ethyl alcohol and phosphorus pentoxide to produce phospholipid, and gradually hydrolyzing the phospholipid to obtain a precursor solution under the effect of ammonium hydroxide; dropping the self-made complexing liquor into the precursor solution to obtain a hydroxy calcium phosphate skeleton, wherein along with the reaction, after the calcium ion and phospholipid are bound to be saturated, one part of barium ions are bound with hydroxyl on the surface of hydroxy calcium phosphate so as to obtain hydroxy calcium phosphate doped with a small amount of barium ions; dissolving tetrabutyl titanate into ethanol, carrying out a blending reaction of the tetrabutyl titanate and the hydroxy calcium phosphate doped with a small amount of barium ions, introducing a titanium source into hydroxy calcium phosphate, and finally calcining, thereby obtaining the high-efficiency bone repair material. The high-efficiency bone repair material prepared by the preparation method disclosed by the invention is capable of realizing high-efficiency repair after transplantation and has wide application prospects.

Description

technical field [0001] The invention relates to a preparation method of a high-efficiency bone repair material, which belongs to the technical field of preparation of artificial medical materials. Background technique [0002] Countries in the world today have entered an aging society, especially China with a large elderly population. Bone disease and dental disease have become common diseases of middle-aged and elderly people and show a younger trend. In recent years, with the rise and breakthrough of research on artificial bones and teeth, new methods have been brought to the treatment of bone and dental diseases. Replacing biological bones and teeth with artificial bones and teeth has also become a major trend in treatment. Hydroxyapatite, HA or HAP for short, molecular formula, plays an important role as one of the important biological materials. It is a surface-active material, and it has similar chemical composition and structure to biological hard tissues. A large...

Claims

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Application Information

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IPC IPC(8): A61L27/02A61L27/12C04B35/447C04B35/622
CPCA61L27/025A61L27/12A61L2430/02C04B35/447C04B35/622C04B2235/3236
Inventor 赵建平张晶
Owner 赵建平
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