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Ultralow pressure generating device, using method and application

A device and pressure generating technology, applied in chemical instruments and methods, ultrafiltration, semi-permeable membrane separation, etc., can solve the problems of increased final benefit, increased adsorption effect and non-specific interception, and reduced macroscopic filtration efficiency of membrane fluid

Active Publication Date: 2021-06-08
杭州佰迈医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, microporous membranes such as chemical membranes or nuclear pore membranes are limited by the support strength and pore size precision. Increasing the membrane pore size has to reduce the porosity of the membrane, so the actual macroscopic filtration efficiency of the fluid passing through the membrane may be reduced instead. If these adsorption effects and non-specific interception are increased, the ultimate benefit of separating clinical or biological samples by ultra-low pressure membranes may not be increased.
Therefore, the existing membrane separation system is unable to perform high-precision, effective and non-destructive separation of cell subpopulations with certain size or stiffness characteristics.
[0006] In addition, the existing membrane separation technology generally requires a large membrane pressure to ensure the filtration flux. Conventional microfiltration or ultrafiltration is generally carried out under a pressure above MPa to ensure a certain filtration rate and a stable filtration rate of the sample. membrane scale

Method used

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  • Ultralow pressure generating device, using method and application
  • Ultralow pressure generating device, using method and application
  • Ultralow pressure generating device, using method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] An ultra-low pressure generating device includes a filter membrane with low membrane-passing resistance, a filter membrane packaging device, and a guide tube; the filter membrane is located between the package devices, and the guide tube 15 is connected to the package device. The microporous filter membrane with low membrane resistance can be used to separate the samples to be filtered; the filter membrane packaging device can be used to fix and encapsulate the filter membrane with low membrane resistance to form a sealed filtration space and prevent the sample from flowing out. The draft tube can be used to generate negative pressure, creating ultra-low pressure.

[0046] The ultra-low pressure generating device can be used to provide the ultra-low pressure required in the filtration process, and the ultra-low pressure is between 0.01KPa and 40KPa.

[0047] In some preferred modes, the filter membrane with low membrane resistance has its own resistance not greater than...

Embodiment 2

[0075] Embodiment 2, with reference to attached Figure 1-5 .

[0076] Specifically, in this embodiment, as Figure 1-5 As shown, the packaging device includes a first fixing part 1, a second fixing part 2 and a sealing part 3, and the first fixing part 1 and the second fixing part 2 are configured to be able to cooperate for fixing and packaging the microporous membrane; The sealing member 3 is an elastic sealing member 3, and the elastic sealing member 3 is located between the first fixing member and the second fixing member, and the elastic sealing member 3 is configured to be able to seal the device, so as to prevent the sample to be filtered from flowing out laterally when filtering. Moreover, the elastic seal is elastic and can be deformed. When the elastic seal contacts the microporous membrane, it will not stab or damage the microporous membrane, which is beneficial to ensure the smoothness of the surface of the microporous membrane. In some preferred manners, the se...

Embodiment 3

[0103] Embodiment 3 is with reference to attached Figure 6 ,8.

[0104] In this example, if Figure 6 As shown, the first fixing member includes a first cavity 4 and a base, and the shape of the first cavity is similar to that of a cone. In other embodiments, the shape of the first cavity 4 may be cuboid, cube, cylinder or other shapes, and the present invention does not limit the specific shape of the first cavity. The size and shape of the first cavity 4 will not affect the negative pressure below the membrane, but the height of the liquid to be filtered on the filter membrane should not be too high, otherwise a non-negligible positive pressure will be generated.

[0105] In some preferred manners, the upper section of the first cavity 4 is provided with a mounting portion for mounting a corresponding cover. The installation part may be an outwardly protruding rib or an inwardly recessed groove or a screw thread or a snap-fit ​​structure, or any other suitable structure ...

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Abstract

The invention discloses an ultra-low pressure generating device, a using method and application. The ultra-low pressure generating device comprises a filter membrane with low membrane passing resistance, filter membrane packaging devices and a flow guide pipe. The filter membrane is located between the packaging devices, the flow guide pipe is connected with the packaging devices, and the filter membrane packaging devices can be used for packaging the filter membrane with low membrane passing resistance to form a sealed filtering space; the flow guide pipe can be used for generating negative pressure to form ultralow pressure; and the ultralow pressure ranges from 0.01 KPa to 40 KPa. The ultra-low pressure generating device can accurately guarantee the power stability of the membrane separation system and control the membrane separation system at the ultra-low pressure separation level, and meanwhile, the whole membrane separation system can effectively solve the technical problem of ultra-low pressure accurate separation of clinical biological samples. The ultra-low pressure generating device can be well applied to clinical and biological fields, is used for separating blood samples, improves the separation efficiency, shortens the separation time, and does not damage or change the cell state in the separation process.

Description

technical field [0001] The invention specifically relates to an ultra-low pressure generating device, a use method and an application. Background technique [0002] From the perspective of clinical sample separation methodology, precise separation methods mainly include: density gradient centrifugation, microfluidic chip separation, flow cytometry, and magnetic bead sorting. Considering the essence of separation, there are two main types: (1) sieving by physical properties (such as density, hardness, size, shape, etc.), and (2) specific adsorption separation by biochemical properties. [0003] As a comprehensive separation method, membrane separation can separate target objects by physical or biochemical properties. The common membrane separation or membrane filtration field is divided into methods such as reverse osmosis filtration, nanofiltration, ultrafiltration and microfiltration. In the biological field, there are membrane separation methods such as separation of nucl...

Claims

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Application Information

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IPC IPC(8): B01D61/14
CPCB01D61/147
Inventor 马萧冯恩慧
Owner 杭州佰迈医疗科技有限公司