Salmeteroxinamic acid ester particles for inhalation and preparation method of salmeteroxinamic acid ester particles

A technology of xinaate and microparticles, which is applied in the field of salmeterol xinaate microparticles for inhalation and its preparation, which can solve the problems of undisclosed active ingredients such as the method of sub-salmeterol micronization, and achieve fine particle size , Avoid powder clogging, high product yield effect
CN112933064APending Publication Date: 2021-06-11SHENZHEN HAIBIN PHARMA
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
SHENZHEN HAIBIN PHARMA
Publication Date
2021-06-11
Patent Text Reader

Abstract

The invention belongs to the technical field of pharmaceutical preparations, and particularly relates to a salmeteroxinamic acid ester microparticle for inhalation and a preparation method thereof, and the salmeteroxinamic acid ester microparticle for inhalation comprises the following components: salmeteroxinamic acid ester and a co-crushing agent in a mass ratio of 1: (10-70). The preparation method comprises the following steps: firstly, according to the mass ratio, mixing salmeteroxamic acid ester with the co-crushing agent for 0.5-1 hour; smashing the mixture obtained in the step 1) in a self-airflow smashing mode, wherein the smashing pressure is 0.6 Mpa, the feeding speed is 0.5 g / min, and obtaining the salmeteroxinamic acid ester particles for inhalation. Compared with independent crushing, the method provided by the invention has the advantages of higher feeding speed and higher product yield, powder blockage in the crushing cavity and the airflow channel is avoided, and the obtained product has smaller particle size.
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Description

technical field

[0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to salmeterol xinacate microparticles for inhalation and a preparation method thereof. Background technique

[0002] Dry powder inhalation preparation (DPI) is a very valuable route of administration, which has the advantages of low dosage, less systemic side effects, fast onset, good therapeutic effect and patient compliance.

[0003] Salmeterol is a long-acting selective β2-adrenoceptor agonist with obvious bronchodilation effect. Salmeterol products include: salmeterol inhalation aerosol, salmeterol powder inhalation, salmeterol plate, for the long-term treatment of reversible airway obstruction and chronic bronchitis of asthma.

[0004] At present, respiratory drug delivery usually has strict requirements on the particle size of the drug, such as pulmonary drug delivery, which usually requires the particle size of the drug to be less than or equa...

Claims

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