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A kind of preparation method of double-loaded pesticide nano-microcapsule suspension

A technology of nano-microcapsules and suspending agents, which is applied in the fields of botanical equipment and methods, pesticides, biocides, etc., can solve the problems of poor solubility and poor stability, and achieve the effect of simple method, low cost, environmental protection and labor saving.

Active Publication Date: 2022-04-12
INST OF ENVIRONMENT & SUSTAINABLE DEV IN AGRI CHINESE ACADEMY OF AGRI SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to provide a method for preparing a double-loaded pesticide nano-microcapsule suspension that can realize the compounding of pesticides with different solubility in view of the defects of poor solubility and poor stability of the existing pesticide single agent

Method used

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  • A kind of preparation method of double-loaded pesticide nano-microcapsule suspension
  • A kind of preparation method of double-loaded pesticide nano-microcapsule suspension
  • A kind of preparation method of double-loaded pesticide nano-microcapsule suspension

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Example 1: Preparation of double-loaded pesticide nano-microcapsule suspension with an average particle size of 500nm-900nm

[0034] Specific steps are as follows:

[0035] (1) Preparation of solid phase

[0036] According to the effective drug content of commercially available water-dispersible granule pesticides, weigh 40 mg of chlorantraniliprole and dissolve in 5 mL of deionized water, then add 0.05 g of polyvinyl alcohol and 0.5 g of bovine serum albumin, and stir evenly with a magnetic stirrer. Prepare a suspension of chlorantraniliprole, which is the solid phase S;

[0037] (2) Preparation of oil phase

[0038] Weigh 40 mg of lambda-cyhalothrin and dissolve it in 20 mL of dichloromethane, then add 0.6 g of polylactic acid, fully dissolve under the action of a magnetic stirrer, and obtain oil phase O;

[0039] (3) Preparation of external water phase

[0040] Weigh 0.48g of polyvinyl alcohol and dissolve it in 120mL of ionized water as the external water phase ...

Embodiment 2

[0044] Example 2: Preparation of double-loaded pesticide nano-microcapsule suspension with an average particle size of 400nm-500nm

[0045] Specific steps are as follows:

[0046] (1) Preparation of solid phase

[0047]According to the effective drug content of commercially available water-dispersible granule pesticides, weigh 40 mg of chlorantraniliprole and dissolve in 5 mL of deionized water, then add 0.05 g of polyvinyl alcohol and 0.5 g of bovine serum albumin, and stir evenly with a magnetic stirrer , prepared into a suspension of chlorantraniliprole, which is the solid phase S;

[0048] (2) Preparation of oil phase

[0049] Weigh 40 mg of lambda-cyhalothrin and dissolve it in 20 mL of dichloromethane, then add 0.6 g of polylactic acid, and fully dissolve it under the action of a magnetic stirrer to obtain oil phase O;

[0050] (3) Preparation of external water phase

[0051] Weigh 0.24% polyvinyl alcohol and dissolve it in 120mL deionized water as the external water...

Embodiment 3

[0055] Example 3: Preparation of double drug-loaded microcapsule suspension with an average particle diameter of about 300nm

[0056] Specific steps are as follows:

[0057] (1) Preparation of solid phase

[0058] According to the effective drug content of commercially available water-dispersible granule pesticides, weigh 40 mg of chlorantraniliprole and dissolve in 5 mL of deionized water, then add 0.05 g of polyvinyl alcohol and 0.5 g of bovine serum albumin, and stir evenly with a magnetic stirrer , prepared into a suspension of chlorantraniliprole, which is the solid phase S;

[0059] (2) Preparation of oil phase

[0060] Weigh 40 mg of lambda-cyhalothrin and dissolve it in 20 mL of dichloromethane, then add 0.6 g of polylactic acid, and fully dissolve it under the action of a magnetic stirrer to obtain oil phase O;

[0061] (3) Preparation of external water phase

[0062] Weigh 0.24% polyvinyl alcohol and dissolve it in 120mL deionized water as the external water phas...

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Abstract

The invention discloses a preparation method of a double-loaded pesticide nano-microcapsule suspension. First, dilute the original drug of chlorantraniliprole with deionized water, then add polyvinyl alcohol and bovine serum albumin to dissolve it as a solid phase (S); dilute lambda-cyhalothrin with dichloromethane, and then add polylactic acid to dissolve it to obtain Oil phase (O); dilute polyvinyl alcohol with deionized water as the external water phase (W); solid phase S is slowly poured into the oil phase under high-speed shear and sheared for one minute to form water-in-oil colostrum, and then After the obtained colostrum is ultrasonically emulsified with a certain power for three minutes, the double-loaded double emulsion system can be obtained; after that, it is centrifuged at a high speed of 10,000rpm for 10 minutes, and centrifuged three times. After each centrifugation, the supernatant is discarded and an equal amount of deionized The water was completely dispersed, and finally volatilized at room temperature for 24 hours to obtain a double-loaded nano-microcapsule suspension. The method of the invention improves the compounding power of different soluble pesticides and simultaneously realizes the slow controlled release of two pesticides.

Description

【Technical field】 [0001] The invention relates to a preparation method of a double-loaded pesticide nano-microcapsule suspension, in particular to coating two pesticides with different solubility into microcapsules layer by layer under certain external force conditions, and belongs to the field of pesticide formulation preparation. 【Background technique】 [0002] my country is one of the largest pesticide consumption countries in the world, but 90% of pesticides are lost in the environment every year or cannot reach the target area required for effective pest control, so the application often exceeds the recommended dosage, causing a lot of waste and pollution. Traditional pesticide formulations such as emulsifiable concentrates, suspension concentrates, and wettable powders have low effective utilization rates, low biological activity, and are greatly affected by climatic conditions, resulting in serious pesticide residues and environmental pollution. [0003] The combinati...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A01N43/56A01N53/08A01N25/18A01N25/28A01N25/04A01P7/04
CPCA01N43/56A01N53/00A01N25/18A01N25/28A01N25/04
Inventor 曾章华冯博媛智亨崔海信
Owner INST OF ENVIRONMENT & SUSTAINABLE DEV IN AGRI CHINESE ACADEMY OF AGRI SCI
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