Ginseng seed quick-release pellet and preparation method thereof

A technology of rapid-release pellets and ginseng seeds, which is applied in the direction of pharmaceutical formulas, medical preparations containing active ingredients, etc., can solve the problem of poor solubility, low bioavailability and collapse of ginseng seed extracts Solve problems such as slow solution, achieve the effect of improving solubility and bioavailability, reducing production costs, and stabilizing immediate release effect

Pending Publication Date: 2021-06-22
深圳前海九华国际投资控股有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to overcome the above-mentioned defects in the prior art, provide a kind of ginseng seed quick-release pellets and its preparation method, aiming to solve the problem of slow disintegration or even direct disintegration of the ginseng seed pellets prepared according to the existing pellets and its preparation method. Non-disintegration leads to poor solubility of ginseng seed extract and technical problems of its low bioavailability

Method used

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  • Ginseng seed quick-release pellet and preparation method thereof
  • Ginseng seed quick-release pellet and preparation method thereof
  • Ginseng seed quick-release pellet and preparation method thereof

Examples

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no. 1 example

[0049] In the first embodiment, the quick-release pellets of ginseng seeds include the following components in parts by weight:

[0050]

[0051] In the second embodiment, the quick-release pellets of ginseng seeds include the following components by weight:

[0052]

no. 3 example

[0053] In the third embodiment, the quick-release pellets of ginseng seeds include the following components by weight:

[0054]

no. 4 example

[0055] In the fourth embodiment, the quick-release pellets of ginseng seeds include the following components in parts by weight:

[0056]

[0057]

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Abstract

The invention discloses a ginseng seed quick-release pellet and a preparation method thereof. The ginseng seed quick-release pellet comprises the components in parts by weight: 5-7 parts of a ginseng seed extract, 20-30 parts of a water-soluble solid dispersion carrier material, 20-40 parts of a filling agent, 3-8 parts of a disintegrating agent and 0-proper amount of an adhesive. The ginseng seed quick-release pellet disclosed by the invention has the characteristic of quickly disintegrating to quickly release the active ingredient ginseng seed extract, so that the solubility and bioavailability of the ginseng seed extract are effectively improved, the effect of the ginseng seed extract can be fully exerted, and the clinical application effect of the ginseng seed extract is improved. According to the preparation method of the ginseng seed quick-release pellet, the process conditions are easy to control, and the prepared ginseng seed quick-release pellet is stable in quick-release effect, high in percent of pass and high in yield.

Description

technical field [0001] The invention belongs to the field of drug controlled-release preparations, and in particular relates to a ginseng seed quick-release pellet and a preparation method thereof. Background technique [0002] Pellets refer to spherical entities with a diameter of less than 2.5mm composed of drug powder and excipients. It belongs to the multi-dose dosage form and can be made into a quick-release drug without time lag. The distribution area of ​​the micropills on the surface of the gastrointestinal tract increases, which can reduce irritation and improve bioavailability; and the micropills are less irritating. [0003] Although the pellets have the above-mentioned advantages, it is also found that the existing reported pellets such as the pellets prepared by the widely used extrusion spheronization technology also have certain deficiencies in clinical practice. If there is slow disintegration or no disintegration directly, the release of the drug is slow, ...

Claims

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Application Information

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IPC IPC(8): A61K9/16A61K36/258A61K47/38A61P35/00A61P25/20A61P39/06A61P9/04A61K131/00
CPCA61K9/1652A61K36/258A61P35/00A61P25/20A61P39/06A61P9/04Y02A50/30
Inventor管悦琴罗雪峰刘亚东
Owner深圳前海九华国际投资控股有限公司