High-stability phloretin nanosuspension, preparation method thereof and microneedle
A nano-suspension and high-stability technology, applied in the direction of microneedle, nanotechnology, nanotechnology, etc., can solve the problems of uneven quality and curative effect, and achieve the effect of good application effect, good mechanical properties, and simple preparation method
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Embodiment 1
[0053] This embodiment provides a phloretin nanosuspension PHL-NIC-NCs, which is prepared by the following method:
[0054] Step 1. Preparation of organic phase solution: Take 10 mg of phloretin (0.036 mmol), dissolve it in 0.5 ml of absolute ethanol, add 4.45 mg of nicotinamide (0.036 mmol), stir and mix thoroughly to obtain an organic phase solution;
[0055] Step 2, preparation of aqueous phase solution: dissolve 20mg of hydroxypropylmethylcellulose HPMC (i.e. the mass ratio of hydroxypropylmethylcellulose to phloretin is 2:1) in 20ml of purified water, and swell at room temperature for 120min , to obtain an aqueous solution;
[0056] Step 3. Under the condition of stirring at 1000rpm, inject the organic phase solution into the aqueous phase solution at a speed of 3-9ml / min, and continue to stir for 0.5min until completely mixed evenly, that is, the phloretin nanosuspension PHL-NIC- NCs.
Embodiment 2-5
[0058] The preparation method of the phloretin nanosuspension provided in Examples 2-5 is roughly the same as that in Example 1, the only difference being that the added molar amounts of nicotinamide are 0.005mmol, 0.02mmol, 0.108mmol and 0.36mmol respectively, That is, in the nanosuspension provided in Examples 1-5, the molar ratios of phloretin and nicotinamide are 1:1, 7.2:1, 1.8:1, 1:3 and 1:10, respectively.
Embodiment 6-8
[0060] The preparation method of the phloretin nanosuspension provided in Examples 6-8 is roughly the same as that in Example 1, the only difference being that the added mass of hydroxypropyl methylcellulose is 5 mg, 10 mg and 50 mg respectively, that is, in In embodiment 1-5, the mass ratio of hydroxypropyl methylcellulose and phloretin is 2:1, and in embodiment 6-8, the mass ratio of hydroxypropyl methylcellulose and phloretin is respectively 1:2, 1:1 and 1:5.
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