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Micro-fluidic chip for tumor marker detection and detection method

A tumor marker and microfluidic chip technology, applied in the field of microfluidic chips, can solve the problems of inability to meet real-time detection, high consumption, limited high-throughput detection capability, etc., and achieve a simple structure, convenient detection, and easy integration. Effect

Pending Publication Date: 2021-06-22
JINAN PANSHENG BIOTECH
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, these methods cannot meet the requirement of instant detection
The traditional detection method - ELISA kit, through detection one by one, consumes a large number of samples to complete the detection of multiple biomarkers
Electrochemical methods have high sensitivity, but their high-throughput detection capabilities are limited

Method used

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  • Micro-fluidic chip for tumor marker detection and detection method
  • Micro-fluidic chip for tumor marker detection and detection method
  • Micro-fluidic chip for tumor marker detection and detection method

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Embodiment Construction

[0027] The following will clearly and completely describe the technical solutions in the embodiments of the present invention with reference to the drawings in the embodiments of the present invention.

[0028] The invention provides a microfluidic chip for tumor marker detection, such as figure 1 As shown, it includes a reaction layer substrate 1 and a microfluidic channel loading layer 2 on it, as figure 2 As shown, the reaction layer substrate 1 includes a glass slide substrate 3 and a graphene oxide quantum dot nanomaterial substrate 4 assembled on the glass slide substrate 3, and a strip detection band is printed on the graphene oxide quantum dot nanomaterial substrate 4 5 and QC strip 6; if image 3 As shown, the bottom of the microchannel sample loading layer 2 is provided with a plurality of microchannel grooves 9, and a plurality of microchannel grooves 9 are vertically arranged with a plurality of strip detection strips 5 and quality control strips 6 to form multip...

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Abstract

The invention discloses a micro-fluidic chip for tumor marker detection and a detection method. The chip comprises a reaction layer substrate and a micro-channel sample adding layer located on the reaction layer substrate, and the reaction layer substrate comprises a glass slide substrate and a graphene oxide quantum dot nanometer material substrate assembled on the glass slide substrate; a strip-shaped detection band and a quality control band are printed on the graphene oxide quantum dot nano material substrate; a plurality of micro-channel grooves are formed in the bottom of the micro-channel sample adding layer, the plurality of micro-channel grooves and the plurality of strip-shaped detection bands and quality control bands are vertically arranged to form a plurality of reaction dot matrixes, and an inflow hole and an outflow hole which are through up and down are further formed in the micro-channel sample adding layer; and two ends of the micro-channel groove are respectively communicated with the inflow hole and the outflow hole. According to the chip and the detection method disclosed by the invention, multiple different tumor markers can be detected at the same time, and the chip and the detection method have the advantages of rapidness, stability and on-site high-throughput detection.

Description

technical field [0001] The invention relates to the field of microfluidic chips, in particular to a microfluidic chip and a detection method for detecting tumor markers. Background technique [0002] Over the past few years, various cancers have seriously affected human health. If tumors are detected early, early treatment and intervention can greatly improve the survival period and survival rate of patients. In the early stage of tumor onset, the concentration of certain biomolecules in human serum begins to change. For example, CEA, CA125, CA199, and CA153 in the serum of breast cancer patients are important markers of breast cancer, and have an important relationship with the diagnosis and prognosis of breast cancer. They are breast cancer-related antigens, which exist in breast cancer cells and can be released into the blood. Detection of the levels of CEA, CA125, CA199, and CA153 in blood can be used to detect breast cancer. The detection of tumor markers in blood or ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/574G01N33/558B01L3/00
CPCG01N33/57484G01N33/558B01L3/5027B01L2200/10
Inventor 韩琳王春华张宇刘宏
Owner JINAN PANSHENG BIOTECH
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