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Novel pharmaceutical composition and application thereof

A drug and drug delivery technology, applied in the field of biomedicine, can solve problems such as damage, adverse drug reactions, poor tumor cell selectivity, etc., and achieve the effect of improving the effect of chemotherapy, reducing the occurrence of adverse reactions, and avoiding drug resistance.

Active Publication Date: 2021-06-25
ZUNYI MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, arsenic trioxide is the same as other chemotherapeutic drugs, because of its poor selectivity to tumor cells, it will inevitably damage the normal cells of the human body while killing cancer cells, resulting in adverse drug reactions, and these toxic and side effects Positive correlation with the amount of arsenic trioxide

Method used

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  • Novel pharmaceutical composition and application thereof
  • Novel pharmaceutical composition and application thereof
  • Novel pharmaceutical composition and application thereof

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0031] Experimental Example 1: Cell Experiment

[0032] 1. Cell selection and active culture

[0033] The experimental selection includes acute promyelocytic leukemia cell NB4, acute promyelocytic leukemia cell HL-60; chronic myeloid leukemia cell K562, human liver cancer cell SMMC-7721, and the above-mentioned cells are cultured in RPMI1640+10% FBS complete medium middle. Human colorectal adenocarcinoma cells CaCo-2 were in DMEM+10% FBS complete medium. The above cells were kept at 37°C with 5% CO 2 , cultured in a cell incubator with saturated humidity.

[0034] 2. Experimental method

[0035] After each tumor cell line is in a stable state, spread the cells in a 96-well plate, 10,000 cells per well for acute promyelocytic leukemia cells NB4, acute promyelocytic leukemia cells HL-60, and chronic myelogenous leukemia cells K562; human liver cancer cells SMMC-7721, human colorectal adenocarcinoma CaCo-2, 3000 cells per well. Each well contained 90 μL of complete medium. ...

experiment example 2

[0061] Experimental example 2: mouse APL model experiment (taking acute promyelocytic leukemia cell NB4 as an example)

[0062] 1. Establishment of leukemia orthotopic transplantation mouse model

[0063] The experimental subjects were 5-week-old NOD / SCID mice, which were cultivated in the SPF animal room of the animal experiment center. The feed, litter, and drinking water used by the mice were sterilized at high temperature, and the litter was changed every 2 days. Supplement water and food in time, and feed adaptively for a week. The mice ready for orthotopic transplantation were pretreated 24 hours before the experiment: 1.5eV was irradiated for 7s, and the mice were injected into the tail vein for the orthotopic transplantation experiment the next day.

[0064] 2. Experimental grouping and dosage (5 groups in total)

[0065] Mice were randomly divided into five groups, 6 in each group, negative control group, positive control group, opzomib group, arsenic trioxide group...

Embodiment 1

[0090] In this embodiment, the injection dose has passed the conversion, which is based on the U.S. Food and Drug Administration (FDA) "Estimating the Safe Starting Dose in Clinical Trials for Drug Clinical Trials" (Estimating the SafeStarting Dose in Clinical Trials for Given in Therapeutics in Adult Healthy Volunteers), the injection dose conversion ratio (1:12.3) of the human body and the mouse (ie, the mouse in the experimental verification) required to achieve the same biological effect. The dose in mice was first tested and then the human dose was calculated. According to the dose of mice, opzomib: arsenic trioxide = 0.43mg / kg: 1.53mg / kg, and then according to the injection dose conversion ratio (1:12.3) of human and mouse, 0.035mg: 0.1245mg, of which 0.1245 is 0.083 Mean of -0.166.

[0091] Opzomib combined with arsenic trioxide chemotherapy drug combination, the drug combination consists of opzomib injection and chemotherapy drug arsenic trioxide injection. Refer to ...

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Abstract

The invention relates to the field of biological medicine, relates to a novel pharmaceutical composition and application thereof, and concretely relates to an arsenic trioxide pharmaceutical composition and application thereof. The pharmaceutical composition is composed of oprozomib and arsenic trioxide, and oprozomib can cooperate with the existing chemotherapeutic drug arsenic trioxide for cancer treatment. Under the condition of using the oprozomib, the dosage of arsenic trioxide for generating a cancer cell inhibition effect is remarkably reduced, so that the probability of adverse reaction of the drug is reduced, and the generation of drug resistance or drug resistance is also avoided to a certain extent. The pharmaceutical composition provided by the invention has a reliable effect and a practical effect of killing malignant tumor cells, and can be applied to medical practices of treatment of various cancers.

Description

technical field [0001] The invention relates to the field of biomedicine, and relates to a new drug combination and its application, in particular to the drug combination of arsenic trioxide and its application. Background technique [0002] Chemotherapy is one of the methods for treating malignant tumors (cancer). It uses chemical drugs to prevent the proliferation, invasion, and metastasis of cancer cells, and finally kills cancer cells. Arsenic trioxide, also known as arsenic, is one of the chemotherapy drugs clinically used to treat leukemia. Clinically, arsenic trioxide injection (also known as injection injection) is used to treat acute promyelocytic leukemia, chronic myeloid leukemia, myelodysplastic syndrome, liver cancer, and colon cancer. Arsenic trioxide has the best curative effect on acute promyelocytic leukemia, and can obtain Satisfactory CR (complete remission of malignant tumor after antitumor treatment). However, arsenic trioxide, like other chemotherapeut...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/06A61K33/36A61P35/00A61P35/02
CPCA61K38/06A61K33/36A61K9/0019A61P35/00A61P35/02A61K2300/00
Inventor 高宁丁鑫龚其海姜秀星申立文王梅
Owner ZUNYI MEDICAL UNIVERSITY
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