A double-network composite hydrogel or hydrogel ball containing nano-silver and its preparation method and application
A technology of composite hydrogel and hydrogel balls, which is applied in the field of biomedical materials, can solve the problems of easy aggregation of silver nanomaterials, achieve good antibacterial effect, less pollution, and overcome the effect of easy aggregation
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Embodiment 1
[0048] A preparation method of a double network composite hydrogel sphere containing nano-silver, the preparation process is as follows:
[0049] (1) Preparation of hot solution containing silver ions:
[0050] Accurately weigh 0.009g of Fmoc- DPhe (Fmoc-D-phenylalanine), was added to the plastic centrifuge tube; continue to accurately weigh 10 mg of HA-GMA (glycidyl methacrylate modified hyaluronic acid) and add it to the aforementioned centrifuge tube; then pipette Put 0.8mL of the prepared sodium phosphate-sodium hydrogen phosphate buffer solution (0.2mol / L, pH 7.4) into the aforementioned centrifuge tube, vortex the centrifuge tube for 1min, and then put the centrifuge tube into a water bath at 85°C for heating. After 20min, Fmoc- D Both Phe and HA-GMA were fully dissolved to form a clear and transparent hot solution;
[0051] Next, accurately weigh 10 mg of Lap and add it to the centrifuge tube, take 1 mL of the previously prepared buffer solution to dissolve the Lap i...
Embodiment 2
[0061] A preparation method of a double-network composite hydrogel containing nano-silver, the preparation process is as follows:
[0062] (1) Preparation of hot solution containing silver ions:
[0063] Accurately weigh 0.009g of Fmoc- D Add Phe (Fmoc-D-phenylalanine) to the plastic centrifuge tube; continue to accurately weigh 10 mg of HA-GMA and add it to the aforementioned centrifuge tube; then pipette 0.8 mL of the prepared sodium phosphate-sodium hydrogen phosphate buffer solution (0.2mol / L, pH value 7.4) into the aforementioned centrifuge tube, vortex shaker shakes the centrifuge tube for 1min, then puts the centrifuge tube into 85°C water bath to heat, after 20min, Fmoc- D Both Phe and HA-GMA were fully dissolved to form a clear and transparent hot solution;
[0064] Next, accurately weigh 10 mg of Lap and add it to the centrifuge tube, take 1 mL of the previously prepared buffer solution to dissolve the Lap in the centrifuge tube; then take 0.1 mL of the prepared La...
Embodiment 3
[0076] A preparation method of a double network composite hydrogel sphere containing nano-silver, the preparation process is as follows:
[0077] (1) Preparation of hot solution containing silver ions:
[0078] Accurately weigh 0.011g of Fmoc- L Add Phe (Fmoc-L-phenylalanine) to the plastic centrifuge tube; continue to accurately weigh 12 mg of HA-GMA and add it to the aforementioned centrifuge tube; then pipette 1.0 mL of the prepared sodium phosphate-sodium hydrogen phosphate buffer solution (0.2mol / L, pH value 7.4) into the aforementioned centrifuge tube, the vortex shaker shakes the centrifuge tube for 2min, and then puts the centrifuge tube into a 90°C water bath to heat, after 30min, Fmoc- L Both Phe and HA-GMA were fully dissolved to form a clear and transparent hot solution;
[0079] Next, accurately weigh 9 mg of Lap and add it to the centrifuge tube, take 1.2 mL of the previously prepared buffer solution to dissolve the Lap in the centrifuge tube; then take 0.1 mL ...
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