Composition containing red orange extract and anti-depression product
A composition and antidepressant technology, applied in the directions of drug combinations, medical preparations containing active ingredients, cosmetics, etc., can solve problems such as rare depression, achieve antidepressant efficacy, increase expression, and improve antidepressant effect.
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Embodiment 1
[0039] This embodiment is the preparation of the essential oil composition, and the specific preparation steps are as follows:
[0040] Red orange essential oil, bergamot essential oil, lemon essential oil, frankincense essential oil, ginger essential oil and gum fir essential oil are respectively 50:50:130:13:5:3, 40:40:104:10:4:2 or The ratio of 30:30:80:7:3:1 was mixed to obtain essential oil compositions, which were recorded as Test Composition 1, Test Composition 2 and Test Composition 3.
Embodiment 2
[0045]This example establishes a mouse model for acute depression induced by reserpine
[0046] Principle: Reserpine inhibits central nervous system activity by depleting catecholamine and 5-hydroxytryptamine (5-hydroxytryptamine, 5-HT) storage in brain tissue, which can cause body temperature drop, upper eyelid ptosis, anhedonia, and weight loss in rodents. Alleviation, decreased exercise capacity, etc.
[0047] Modeling: 5-week-old male KM mice (30±5g) were fed adaptively for one week before modeling. Reserpine is ready-to-use, the preparation concentration is 0.6mg / mL, except the blank group, the other groups are injected intraperitoneally according to the amount of 0.1mL / 10g of mouse body weight, and the dosage is 6mg / kg. Mice were given a single intraperitoneal injection of reserpine (6 mg / kg), which resulted in depressive symptoms lasting 72 hours after the injection. The blank group was given i.p. injection of DMSO / normal saline on the same day, and the behavioral tes...
Embodiment 3
[0050] This embodiment carries out forced swimming test (FST)
[0051] Put the mouse into a transparent glass tank with a diameter of 25 cm and a height of 30 cm, filled with 15 cm high water, the water temperature is 21-25 °C, the total recording time is 360 s, and the recorded data is within 120-360 s. The percentage of time the mouse is floating or slightly moving, which is used to reflect the degree of helplessness of the mouse.
[0052] It can be seen from Table 1 that the essential oil compositions containing tangerine essential oil provided by experimental groups 1-3 can significantly shorten the swimming immobility time of mice.
[0053] From the experimental results in Table 1, it can be known that the experimental group 2 has the best antidepressant effect on the mice. Therefore, the present invention uses the experimental group 2 to compare with other groups and conduct subsequent experiments.
[0054] figure 1 It is the histogram of antidepressant-FST immobility ...
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