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Taste masking agent formula for reversibly covering up oral bitter taste by using medicine in advance

A taste-masking, reversible technology, applied in the field of pharmaceutical excipients, can solve problems such as unscientific experimental methods

Pending Publication Date: 2021-07-06
ZHENGZHOU WEIQIAN BIOTECHNOLOGY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Aiming at the deficiencies of the prior art, the present invention provides a taste-masking agent formula that reversibly masks the bitterness of the oral cavity through pre-medication, which has the advantages of scientific experiments and masking the bitterness of traditional Chinese medicines, and solves the problem of bitter taste and experimentation of traditional Chinese medicines mentioned in the background technology. The problem of unscientific methods

Method used

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  • Taste masking agent formula for reversibly covering up oral bitter taste by using medicine in advance
  • Taste masking agent formula for reversibly covering up oral bitter taste by using medicine in advance
  • Taste masking agent formula for reversibly covering up oral bitter taste by using medicine in advance

Examples

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Effect test

Embodiment 1

[0037] This example is an example of screening and discovering active ingredients in the patent of the taste-masking agent formula that can reversibly mask the bitter taste in the oral cavity through pre-medication, that is, active ingredients that mask the bitter taste by masking the oral taste buds or anesthetizing the oral nerves.

[0038] see Figure 1-15 , the taste-masking agent formula for reversibly masking the bitterness of the oral cavity by pre-medication, including the composition of the taste-masking agent drug, the composition of the taste-masking agent drug includes: anesthetic or taste-masking agent, sweetener, sour agent, thickener, Penetration enhancer, the taste-masking agent drug is composed of at least one component, and the anesthetic or taste-masking agent must contain it.

[0039]Through the above technical scheme, like other senses of taste, bitterness is a sensation caused by the stimulation of liquid containing chemical substances. Taste receptors a...

Embodiment 2

[0057] This example is an example of concentration-taste-masking effect experiments conducted on active ingredients discovered through screening of a taste-masking agent formula patent that can reversibly mask the bitterness of the oral cavity through pre-medication.

[0058] Concentration-taste masking effect experiments are carried out on the active ingredients found through screening, and then the optimal concentration for use is found.

[0059] When using Asarum for taste-masking treatment, its own peculiar smell is related to its concentration, and the taste-masking effect is better at 10g / 160ml, and the sense of peculiar smell itself is reduced at the same time, such as Figure 14 with Figure 15 As shown; when using tannic acid for taste-masking treatment, the taste-masking effect increases with the increase of the concentration, by Figure 8 with Figure 9 It can be seen that when the concentration of tannin is 0.60%, the astringency itself is barely acceptable; when...

Embodiment 3

[0069] This example is an example in which other ingredients are added to form a compound taste-masking agent and the taste-masking effect is verified after the effective drug and drug concentration are screened out in the above-mentioned embodiment of the formula of the taste-masking agent for reversibly masking the bitter taste of the oral cavity by pre-medication .

[0070] The taste-masking agent formula for reversibly masking the bitterness of the oral cavity by pre-medication, the composition of the taste-masking agent includes: anesthetic or taste-masking agent, sweetener, sour agent, thickener, At least one component of the penetration enhancer, in which the anesthetic or flavor masking agent must be contained.

[0071] Specifically, obtain substances that can reversibly mask the bitter taste of drugs for a certain period of time by anesthetizing the nerves, including five kinds of substances including menthol, asarum, articaine, clove oil, and pepper essential oil, an...

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Abstract

The invention relates to the technical field of pharmaceutical excipients, and discloses a taste masking agent formula for reversibly covering up oral bitter taste by using a medicine in advance. The taste masking agent formula comprises taste masking agent medicine components and a medicine experiment method, wherein the taste masking agent medicine components comprise articaine, a dry medicinal material, a sweetener, a sour agent, a thickener and a penetration enhancer; the thickener is a mixed solution of polyethylene glycol, cellulose, polyvinyl alcohol, carbomer, xanthan gum, gelatin, carrageenan and sodium alginate; and the penetration enhancer is a solution prepared from one of menthol, asarum and tannic acid. According to the taste masking agent formula for reversibly covering up oral bitter taste by using the medicine in advance, by adding the sweetener, the sour agent, the thickener and the penetration enhancer which are harmless to a human body, a user can cover up the bitter taste through the taste masking agent when taking the traditional Chinese medicine, and then when the traditional Chinese medicine needs to be taken orally, the user can firstly keep the taste masking agent in the mouth for mouth rinsing, so that the bitter taste of the traditional Chinese medicine during taking can be fully covered up by a way of rinsing the mouth in advance, and the problem that the concentration and effect cannot be ensured due to the fact that a traditional taste masking agent is directly decocted with the traditional Chinese medicine at the same time is solved.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical excipients, in particular to a taste-masking agent formula for reversibly masking the bitter taste of the oral cavity through premedication. Background technique [0002] Traditional Chinese medicine has a long history as a traditional medicine for treating diseases in my country, and its curative effect is remarkable. According to statistics, among the 618 kinds of medicinal materials and decoction pieces included in the 2015 edition of "Chinese Pharmacopoeia", bitter medicinal materials account for more than 60%. Among them, the most common types of bitter substances mainly include the following three categories: 1. Alkaloids, such as berberine mainly contained in Cortex Phellodendri and Coptidis Rhizoma, strychnine in Nuxychnya, liensinine in lotus seeds, and ephedra in ephedra Alkali, etc.; 2. Terpenoids, also known as bitters, generally have a bitter taste due to the structure that can f...

Claims

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Application Information

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IPC IPC(8): A61K47/46A61K47/44A61K47/26A61K47/10A61K47/22
CPCA61K47/44A61K47/26A61K47/46A61K47/10A61K47/22A61K9/006
Inventor 张景亮程红娜颜国华谷晨萌张蒙蒙陈文倩
Owner ZHENGZHOU WEIQIAN BIOTECHNOLOGY CO LTD
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