Integrated tear separation detection device and preparation method thereof
A spectral detection and solution technology, applied in the field of an integrated tear separation detection device and its preparation, can solve the problems of false positives, sensor contamination, and reduce the sensitivity and specificity of the measurement, and achieve the effect of reducing interference and influence.
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Embodiment 1
[0065] (1) Synthesis of silica microspheres
[0066] Mix 10 mL of ammonia water, 6 mL of deionized water and 50 mL of ethanol, preheat at a constant temperature in an oil bath at 30°C for several minutes, then add 10 mL of ethyl orthosilicate dropwise to the above mixed solution and stir vigorously, the color of the solution gradually changes to Light white, 800nm silica microspheres can be obtained after 12h. After the reaction, take out and centrifuge at 4000rpm for 10min to remove unreacted raw materials, then disperse the sediment at the bottom of the centrifuge tube into methanol solution, and repeat the centrifugation three times for further purification; 5% mass fraction of silica microsphere suspension. The prepared suspension should be stored in a refrigerator at 4°C to prevent microsphere aggregation.
[0067] (2) Hydrophilic treatment of glass sheets
[0068] Cut glass pieces into 2×1cm 2 size, sonicated in deionized water to remove surface impurities. Use co...
Embodiment 2
[0077] (1) Synthesis of silica microspheres
[0078] Mix 8 mL of ammonia water, 7 mL of deionized water and 600 mL of ethanol, preheat at a constant temperature of 60°C in an oil bath for several minutes, then add 8 mL of ethyl orthosilicate dropwise to the above mixed solution and stir vigorously, the color of the solution gradually changes to Light white, 1000nm silica microspheres can be obtained after 12h. After the reaction, take out and centrifuge at 3000 rpm for 5 min to remove unreacted raw materials, then disperse the sediment at the bottom of the centrifuge tube into methanol solution, repeat the centrifugation twice for further purification; A silica microsphere suspension with a mass fraction of 2.5% was obtained. The prepared suspension should be stored in a refrigerator at 4°C to prevent microsphere aggregation.
[0079] (2) Hydrophilic treatment of glass sheets
[0080] Cut glass pieces into 1.5×2cm 2 size, sonicated in deionized water to remove surface impu...
Embodiment 3
[0089] This embodiment provides an integrated tear separation detection device, refer to image 3 and Figure 4 , the device includes a first substrate 1 and a second substrate 2 that are opposite and spaced apart and a spacer sandwiched between the first substrate 1 and the second substrate 2; the first substrate 1 and the second substrate 2 A capillary cavity is formed between them; the capillary cavity has at least one liquid inlet; the first substrate 1 is the surface-enhanced Raman spectroscopy detection substrate prepared in Example 1 or Example 2, and the gold nanoparticle layer and the The second substrates 2 are arranged opposite to each other. When the liquid inlet is in contact with the tear liquid, the capillary cavity attracts and accommodates the tear liquid to be tested through capillary action.
[0090] In a preferred embodiment, the first substrate 1 and the second substrate 2 respectively have a first protrusion 11 and a second protrusion 21 at the liquid i...
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