Unlock instant, AI-driven research and patent intelligence for your innovation.
A kind of preparation method and application of bifluoroboron fluorescent dye responsive to triethylamine
What is Al technical title?
Al technical title is built by PatSnap Al team. It summarizes the technical point description of the patent document.
A fluorescent dye and triethylamine technology, which is applied in the direction of luminescent materials, organic dyes, azo dyes, etc., can solve the problems of long reaction time, complicated operation method of triethylamine, low sensitivity, etc., and achieve fast detection and stable peak value change , the effect of low fluorescence intensity
Active Publication Date: 2022-08-09
CHINA THREE GORGES UNIV
View PDF5 Cites 0 Cited by
Summary
Abstract
Description
Claims
Application Information
AI Technical Summary
This helps you quickly interpret patents by identifying the three key elements:
Problems solved by technology
Method used
Benefits of technology
Problems solved by technology
[0004] Most of the existing domestic and foreign methods of using different fluorescent probes to detect triethylamine have defects such as complicated operation methods, long reaction time, and low sensitivity.
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more
Image
Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
Click on the blue label to locate the original text in one second.
Reading with bidirectional positioning of images and text.
Smart Image
Examples
Experimental program
Comparison scheme
Effect test
Embodiment 1 Embodiment 1
[0023] Example 1 Example 1 Synthesis of Probe Molecules
Embodiment 1-1
[0025] Take compound 1 (598 mg, 2 mmol); salicylaldehyde (1.96 ml, 2 mmol), TsOH (34.2, mg, 0.2 mmol) were dissolved in DCM (60 ml), stirred at 35 ° C for 12 h, and the reaction was monitored by spot plate until the raw materials were completely reacted, After neutralization with alkali, the product was washed with water, extracted, dried, rotary evaporated, and purified by filtration to obtain compound 3 (216 mg, yield 26.7%). Take the above compound 3 (202mg, 0.5mmol), add 20ml dichloromethane solution, 1.00ml triethylamine, under electromagnetic stirring, slowly add borontrifluorideether solution (1.00ml) dropwise, raise the temperature to 35 ℃ , refluxed for 30 min, TLC spot plate detection, the product was washed with water, extracted, dried, rotary evaporated, filtered and purified to obtain compound I as a golden yellow solid (194 mg, yield 86%).
[0026]
Embodiment 1-2
[0028] Take compound 1 (598 mg, 2 mmol); salicylaldehyde (1.96 ml, 2 mmol), TsOH (17.1, mg, 0.1 mmol), dissolve in DCM (60 ml), stir at 35 ° C for 12 h, and monitor the reaction by spotting until the raw materials are completely reacted, After neutralization with alkali, the product was washed with water, extracted, dried, rotary evaporated, and purified by filtration to obtain compound 3 (299 mg, yield 37%). Take the above compound 3 (202mg, 0.5mmol), add 20ml dichloromethane solution, 1.00ml triethylamine, under electromagnetic stirring, slowly add borontrifluorideether solution (1.00ml) dropwise, raise the temperature to 35 ℃ , refluxed for 30 min, TLC spot plate detection, the product was washed with water, extracted, dried, rotary evaporated, filtered and purified to obtain compound I as a golden yellow solid (198.4 mg, yield 88%). Compared with Example 1-1, the amount of p-toluenesulfonic acid was reduced by half, and the yield of compound 3 was increased by 10.3%.
...
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More
PUM
Login to View More
Abstract
The invention discloses a preparation method and application of a fluorescent dye with a bifluoroboron structure responsive to alkalis. Heptafluoroboron compound 1 and dichloromethane are added to a reaction flask at room temperature, stirred and dissolved, and then saliculus is added. Aldehyde and p-toluenesulfonic acid are heated and refluxed to react to obtain reaction solution 1, the temperature of heating and refluxing reaction is 35-40 ° C, and refluxing for 2-18 h; then add dichloromethane, triethylamine, and slowly add borontrifluorideether complex dropwise compound, heating and refluxing reaction to obtain reaction solution 2, heating and refluxing reaction temperature is 35-40 DEG C, refluxing for 2-18h to obtain a double fluoroboron structure fluorescent dye compound. The molar amount of triethylamine can be distinguished by different fluorescence intensities, and the change of the molar amount of triethylamine in the DCM liquid environment can be detected. Ethylamine has a large molar range, and is not color-producing in acidic and neutral solutions, that is, stable in the fluorescence spectrum.
Description
technical field [0001] The invention discloses a preparation method and application of a fluorescent dye with a bifluoroboron structure responsive to triethylamine, in particular to a fluorescent dye that can distinguish the molar amount of triethylamine by different fluorescence intensities, and can detect DCM Changes in the molar amount of triethylamine in a liquid environment. Background technique [0002] Triethylamine is a volatile organic amine, which is a moderately toxic compound. If inhaled, it may cause abnormal symptoms in the respiratory organs and blood circulatory system, including the central system and the body's liver. It can cause oral corrosion and even pulmonary edema and cause chemical burns. For female patients, if the components of triethylamine are inhaled, infertility will also occur. [0003] Triethylamine is often used as an acid binding agent in production, and is finally discharged as wastewater. The concentration of triethylamine in wastewater...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More
Application Information
Patent Timeline
Application Date:The date an application was filed.
Publication Date:The date a patent or application was officially published.
First Publication Date:The earliest publication date of a patent with the same application number.
Issue Date:Publication date of the patent grant document.
PCT Entry Date:The Entry date of PCT National Phase.
Estimated Expiry Date:The statutory expiry date of a patent right according to the Patent Law, and it is the longest term of protection that the patent right can achieve without the termination of the patent right due to other reasons(Term extension factor has been taken into account ).
Invalid Date:Actual expiry date is based on effective date or publication date of legal transaction data of invalid patent.
Login to View More 
Login to View More