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Composition of tolperidone hydrochloride and application thereof

A technology of tolperidone hydrochloride and a composition is applied in the field of the composition of tolperidone hydrochloride, which can solve the problems of not paying attention to the safety of components of tolperidone hydrochloride, achieve good cardiovascular protection, enhance activity, and enhance The effect of immunity

Active Publication Date: 2021-07-13
GUANGDONG YILI GROUP PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0008] CN1919255A discloses a kind of Naoluotong dripping pill, which comprises the medicinal composition of salvia miltiorrhiza extract, tolperone hydrochloride, chuanxiong extract, methyl hesperidin, astragalus extract, and vitamin B6. , high bioavailability, etc., but did not pay attention to the safety of the topaperone hydrochloride components

Method used

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  • Composition of tolperidone hydrochloride and application thereof

Examples

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preparation example Construction

[0037] The present invention also provides a preparation method of the above-mentioned tolperone hydrochloride pharmaceutical composition, comprising the following steps:

[0038] S1, crushing Noni fruit and Schisandra chinensis to obtain a fine powder with a particle size of 30-50 μm;

[0039] S2. Add ethanol aqueous solution to the fine powder material obtained in step S1, and extract in a water bath to obtain an extract; the mass ratio of fine powder material and ethanol aqueous solution described in step S2 is 1:10-15; the mass percentage of the ethanol aqueous solution 70-75%; the conditions of the water-bath extraction are: 2-3 hours of water-bath extraction at 70-85°C;

[0040] S3. Add tolperone hydrochloride and cyclodextrin to the extract obtained in step S2, mix well, concentrate under reduced pressure, dry and pulverize to obtain the pharmaceutical composition of tolperone hydrochloride; the cyclodextrin The added amount of the essence is 0.03-0.05% of the mass of ...

Embodiment 1-6

[0044] Embodiment 1-6 a kind of tolperone hydrochloride pharmaceutical composition and preparation method thereof

[0045] The raw materials and consumption (parts by weight) of the tolperone hydrochloride pharmaceutical composition described in Examples 1-6 are shown in Table 1.

[0046] Table 1

[0047] Example 1 Example 2 Example 3 Example 4 Example 5 Example 6 Tolperone Hydrochloride / part 20 50 25 45 40 35 Noni fruit / serve 10 25 11 24 20 15 Schisandra / serving 16 8 14 9 12 10

[0048] The preparation method of above-mentioned tolperone hydrochloride pharmaceutical composition, comprises the following steps:

[0049] S1, pulverizing noni fruit and schisandra to obtain a fine powder with a particle size of 40 μm;

[0050] S2, add ethanol aqueous solution to the fine powder material that step S1 obtains, extract in water bath, obtain extract; The mass ratio of fine powder material described in step S2 and ethanol aq...

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Abstract

The invention belongs to the technical field of medicines, and discloses a tolperidone hydrochloride pharmaceutical composition and an application thereof. The tolperidone hydrochloride pharmaceutical composition is prepared from the following raw materials: tolperidone hydrochloride, morinda citrifolia and schisandra chinensis. The application refers to the application of the tolperidone hydrochloride pharmaceutical composition in preparation of drugs for treating heart and cerebral vessels. The morinda citrifolia and the schisandra chinensis are selected to be compounded with the tolperidone hydrochloride, so that on one hand, the side effect of the tolperidone hydrochloride can be reduced, the occurrence of anaphylaxis can be reduced, and on the other hand, the activity of the tolperidone hydrochloride can be improved, and the formation of arterial thrombosis can be effectively prevented.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a composition of tolperone hydrochloride and an application thereof. Background technique [0002] Cardiovascular Disease (CVD) is a disease that threatens human health worldwide. Its onset is hidden, with a long incubation period, and it is difficult to recover after onset. With the development of my country's economy and the improvement of people's living standards, the prevalence and mortality of cardiovascular diseases in my country are increasing year by year, and the incidence is younger. [0003] Tolperisone Hydrochloride, molecular formula C 16 h 24 ClNO; molecular weight 281.83, structural formula: [0004] [0005] Tolperone hydrochloride is a central muscle relaxant, and its indications are for the treatment of ischemic vascular diseases, such as arteriosclerosis, endovascular disease, etc.; it is also suitable for sequelae of stroke, cerebral palsy,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/746A61K31/4453A61P9/10A61P7/02
CPCA61K31/4453A61K36/746A61K36/57A61P9/10A61P7/02A61K2236/333A61K2300/00
Inventor 张小勇李霞张浩潘洁丽李志军
Owner GUANGDONG YILI GROUP PHARMA
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