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Target ZIP7 related to diagnosis, treatment, prevention and treatment of cardiovascular diseases and application of target ZIP7

A myocardial infarction and myocardial technology, applied to the target ZIP7 related to the diagnosis, treatment and prevention of cardiovascular diseases and its application fields, to achieve the effect of reducing myocardial oxidative stress

Inactive Publication Date: 2021-07-23
TIANJIN MEDICAL UNIV
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Problems solved by technology

More and more studies have shown that mitophagy plays an important protective role in myocardial ischemia-reperfusion injury, but there is no drug or means to induce mitophagy

Method used

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  • Target ZIP7 related to diagnosis, treatment, prevention and treatment of cardiovascular diseases and application of target ZIP7
  • Target ZIP7 related to diagnosis, treatment, prevention and treatment of cardiovascular diseases and application of target ZIP7
  • Target ZIP7 related to diagnosis, treatment, prevention and treatment of cardiovascular diseases and application of target ZIP7

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Embodiment Construction

[0090] In order to enable those skilled in the art to better understand the technical solutions of the present invention, the present invention will be further described in detail below in conjunction with the accompanying drawings and preferred embodiments.

[0091] Zinc is an essential trace element to maintain the normal cell structure and function of the human body. Most zinc is bound to proteins and plays an important role in many metabolisms, and its homeostasis is tightly regulated by many proteins, especially zinc transporters. Mammalian zinc transporters are divided into two families: ZnT (SLC30) and Zip (SLC39) zinc transporters. In the regulation of zinc homeostasis, ZnT and ZIP transporters play opposite roles. The ZnT family assists the outflow of zinc ions from the cytoplasm to the outside of the cell or into the organelle to reduce the concentration of free zinc in the cytoplasm; while the ZIP transporter promotes the release of zinc ions from the cytoplasm to t...

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Abstract

The invention discloses a target ZIP7 related to diagnosis, treatment, prevention and treatment of cardiovascular diseases and application of the target ZIP7. The application of a substance for inhibiting or silencing ZIP7 gene expression or inhibiting ZIP7 protein activity in any one of the following conditions that a medicine for increasing the concentration of zinc ions in mitochondria is prepared; a medicine for reducing the mitochondrial membrane potential is prepared; a medicine for increasing aggregation of PINK1 in mitochondria is prepared; a medicine for increasing the aggregation of Parkin in mitochondria is prepared; a medicine for inducing mitochondrial autophagy is prepared; a medicine for reducing the release level of active oxygen in myocardial tissues is prepared; a medicine for reducing the myocardial infarction risk is prepared; a medicine for treating or adjunctively treating myocardial infarction is prepared; a medicine for improving the cardiac function after myocardial infarction is prepared; a medicine for inhibiting the enlargement of the infarction area after myocardial infarction is prepared; a medicine for inhibiting ventricular negative remodeling after myocardial infarction is prepared; a medicine for reducing damage of myocardial cells and myocardial tissues in the myocardial infarction process is prepared; and a medicine for reducing the death quantity of myocardial cells in a non-infarction region after myocardial infarction is prepared.

Description

technical field [0001] The invention relates to the field of biotechnology, in particular to a target ZIP7 related to the diagnosis, treatment and prevention of cardiovascular diseases and its application. Background technique [0002] Myocardial ischemic injury caused by acute myocardial infarction is very common clinically and its consequences are very serious, often leading to myocardial necrosis, arrhythmia, cardiac insufficiency, heart failure and even death. In recent years, the research on myocardial ischemic injury has made great progress. Many experimental studies have proved that many drugs can reduce ischemic injury, but the clinical effect is very little. This is mainly because in most experimental studies, drug administration (pretreatment) is performed before the occurrence of ischemia, which is obviously inconsistent with the actual clinical situation, because clinically most patients have already had infarction before they rushed to the emergency room, and pr...

Claims

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Application Information

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IPC IPC(8): A61K45/00A61P9/10A61P9/00
CPCA61K45/00A61P9/10A61P9/00
Inventor 徐哲龙张华璐
Owner TIANJIN MEDICAL UNIV
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