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Pharmaceutical composition containing aucuba japonica extract for preventing or treating macular degeneration

A macular degeneration and peach leaf coral technology, applied in the direction of drug combination, medical preparations containing active ingredients, food science, etc., can solve problems such as inability to achieve fundamental treatment, and achieve inhibition of retinal optic nerve cell damage and choroidal neogenesis. Angiogenesis, photo-oxidative inhibition effect

Active Publication Date: 2021-07-23
IND COOP FOUND CHONBUK NAT UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Various treatment methods have been developed for macular degeneration, but fundamental treatment to suppress the progression of symptoms cannot be achieved, and prevention is more important than treatment

Method used

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  • Pharmaceutical composition containing aucuba japonica extract for preventing or treating macular degeneration
  • Pharmaceutical composition containing aucuba japonica extract for preventing or treating macular degeneration
  • Pharmaceutical composition containing aucuba japonica extract for preventing or treating macular degeneration

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] Embodiment 1. The preparation of the ethanol reflux extract of coral acanthus

[0051] The leaves and stems of Peach coral were collected in Jisepo-ri Forest, Ilun-myeon, Geoje-si, Gyeongsangnam-do in August 2018, and the evidence specimens are kept in the reagent storage room of Chonbuk National University. Add 50g of Coralia acanthus (leaf and stem mixture) into 1500ml of 30% ethanol (w / w), extract at 70-100°C by reflux once every 3 hours, concentrate under reduced pressure and freeze-dry to obtain 30% Ethanol reflux extracts.

Embodiment 2

[0052] Embodiment 2. The preparation of the hot water extract of Coral acanthus

[0053] The leaves and stems of Peach coral were collected in Jisepo-ri Forest, Ilun-myeon, Geoje-si, Gyeongsangnam-do in August 2018, and the evidence specimens are kept in the reagent storage room of Chonbuk National University. After that, 900 ml of distilled water was added to 50 g (leaf and stem mixture) of Coralia persicae, heated at 100° C. for 3 hours, concentrated under reduced pressure, and then dried to prepare a hot water extract of Coralia persicae.

Embodiment 3

[0054] Example 3. Analysis of aucubin content by HPLC analysis of the extracts of Aucaudophyllum

[0055] 3-1. Reagents and equipment

[0056] The standard product aucubin (aucubin: purity 99.5%) was purchased from Chengdu Purifa Technology Development Co., Ltd. (Chengdu, China). The mobile phase solvent acetonitrile and water (J.T.Backer, USA) used for HPLC analysis all use HPLC grade. In the HPLC analysis, the 1200analytical HPLC system of Agilent Technologies was used. Injector (G1329A) constitutes. Chemworkstation software is used for equipment operation and analysis result processing.

[0057] 3-2. Preparation of standard solution and establishment of calibration curve

[0058] The standard product aucubin (aucubin) was dissolved in MeOH at a concentration of 2mg / mL, diluted in stages, and standard solutions for calibration curves were prepared at concentrations of 2000, 1000, 500, and 100ug / mL, respectively. Each calibration curve was injected into a column with a s...

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Abstract

The present invention relates to a pharmaceutical composition containing Aucuba japonica extract for preventing or treating macular degeneration.

Description

technical field [0001] This application claims the priority of Korean Patent Application No. 10-2018-0157405 filed on December 07, 2018, and the entire specification is a reference of this application. The present invention relates to a pharmaceutical composition for the prevention or treatment of macular degeneration comprising an extract of Coralia acanthus. Background technique [0002] The nerve tissue located in the center of the inner retina of the eye is called the macula. The cone cells in the visual cells are densely packed, and the center of the macula is where the images of objects gather, so it plays an extremely important role in vision. The so-called visual acuity refers to the ability to recognize the existence and shape of objects. The image of an object is most acute when it gathers in the fovea of ​​the macula (central vision), and it decreases toward the periphery of the retina (peripheral vision). When the macula is deformed or its function declines due ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/185A61P27/02A23L33/105
CPCA23L33/105A61K36/185A61P27/02A61K2236/00A23V2002/00A23L33/40A61K2236/333
Inventor 金正玹
Owner IND COOP FOUND CHONBUK NAT UNIV
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