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Gastric retention agent as well as preparation method and application thereof

A gastric retention and solvent technology, which is applied in the field of medicine to increase absorption, reduce the number of administrations, and achieve the effect of exerting efficacy

Active Publication Date: 2021-07-27
TIANJIN UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to current safety concerns with long-term use of PPIs, there is a need to find effective and safe alternatives for the treatment of GERD

Method used

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  • Gastric retention agent as well as preparation method and application thereof
  • Gastric retention agent as well as preparation method and application thereof
  • Gastric retention agent as well as preparation method and application thereof

Examples

Experimental program
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Effect test

preparation example Construction

[0032] The second aspect of the present application provides a preparation method of the gastric retention agent of the present application, which includes the steps of dissolving the polysaccharide from white and polysaccharides in a solvent, and then adding a solid excipient or a liquid excipient.

[0033] The third aspect of the present application provides the use of the gastric retention agent of the present application in the preparation of a medicament for preventing and / or treating gastroesophageal reflux disease and / or gastric ulcer.

[0034]The fourth aspect of the present application provides a pharmaceutical composition, comprising the gastric retention agent of the first aspect of the present application, and at least one of Chinese medicine, Chinese medicine extract or chemical medicine, said Chinese medicine, Chinese medicine extract or chemical medicine The concentration of the medicine is 5-60 mg / mL, and the ratio of the concentration of the traditional Chinese...

preparation example 1

[0042] Dissolve 1.5g of Baiji polysaccharide with a purity of 98% in 80mL of pure water, then add 20mL of glycerol monooleate (GMO), and stir (electric stirring at 1000r / min) until completely dispersed to obtain gastric retention agent; wherein, the concentration of Baiji polysaccharide is 15mg / mL, and the volume fraction of GMO is 20%.

preparation example 2-14

[0044] The polysaccharides, solvents and excipients of Baiji in Preparation Examples 2-14 in Table 1 were taken, and each gastric retention agent was prepared according to the preparation method of Preparation Example 1.

[0045] Table 1 prepares the raw material of gastric retention agent and the composition of gastric retention agent prepared

[0046]

[0047]

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Abstract

The invention provides a gastric retention agent for preventing and / or treating gastroesophageal reflux disease as well as a preparation method and an application thereof. The gastric retention agent for preventing and / or treating the gastroesophageal reflux disease comprises rhizoma bletillae polysaccharide, an excipient and a solvent, wherein the excipient is selected from at least one of higher fatty acid esters, fatty alcohols, fatty acids, wax-like wax and wax-like wax additives; the solvent is selected from pure water or weak base water; the concentration of the rhizoma bletillae polysaccharide is 5-60 mg / mL; the excipient is a solid excipient, and the concentration of the excipient is 50-400 mg / mL or the excipient is a liquid excipient, and the volume fraction of the excipient is 5-40%. The gastric retention agent can be used for preparing the medicine for preventing and / or treating the gastroesophageal reflux disease and / or gastric ulcer, and can also be used for preparing the medicine for preventing and / or treating the gastroesophageal reflux disease and simultaneously preventing and / or treating other gastrointestinal diseases.

Description

technical field [0001] The present application relates to the technical field of medicine, in particular to a gastric retention agent, its preparation method and application. Background technique [0002] Gastroesophageal reflux is a disease in which clinical gastroesophageal reflux disease and esophageal mucosal damage caused by excessive contact (or exposure) of the gastroesophageal lumen are called gastroesophageal reflux. The causes of gastroesophageal reflux are affected by various factors such as pathological factors (including decreased lower esophageal sphincter pressure, decreased esophageal clearance capacity, impaired esophageal mucosal barrier, hypersensitivity of esophageal viscera, etc.), environmental factors, genetic factors, and lifestyle. . The main clinical manifestations are 1. Heartburn and acid reflux. Heartburn refers to the burning sensation behind the sternum and under the xiphoid process, which usually occurs one hour after a meal. It is easy to o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/715A61K36/898A61K45/06A61K9/00A61P1/04A61P1/00
CPCA61K31/715A61K36/898A61K45/06A61K9/0065A61K47/14A61K47/12A61K47/10A61K47/44A61P1/04A61P1/00A61K2300/00Y02A50/30
Inventor 王萌任晓亮刘亚男孙立丽姜苗苗刘虹陈美玲孔艳李娜
Owner TIANJIN UNIV OF TRADITIONAL CHINESE MEDICINE