Application of scutellaria baicalensis decoction in preparation of medicine for treating diarrhea and improving intestinal function

A medicine and the technology of scutellaria baicalensis are applied in the application field of scutellaria baicalensis decoction in the preparation of medicines for treating diarrhea and improving intestinal function, which can solve the problems such as the lack of relevant disclosure of the effective effect of scutellaria baicalensis decoction, the limitation of effective utilization of scutellaria baicalensis decoction, and the like, and achieve an increase in relative abundance. The effect of improving intestinal flora and relieving diarrhea symptoms

Pending Publication Date: 2021-07-30
INST OF ANIMAL HEALTH GUANGDONG ACADEMY OF AGRI SCI
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  • Abstract
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Problems solved by technology

[0005] At present, the effect of Huangqin Decoction in treating castor oil-induced diarrhea and its related mechanism are still blank, and there is no relevant disclosure about the effective effect of Huangqin Decoction on other aspects of the gastrointestinal tract, which limits the effective use of Huangqin Decoction. Developed a wider range of new applications for Huangqin Decoction

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  • Application of scutellaria baicalensis decoction in preparation of medicine for treating diarrhea and improving intestinal function
  • Application of scutellaria baicalensis decoction in preparation of medicine for treating diarrhea and improving intestinal function
  • Application of scutellaria baicalensis decoction in preparation of medicine for treating diarrhea and improving intestinal function

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Embodiment Construction

[0065] In order to make the object, technical solution and technical effect of the present invention clearer, the present invention will be further described in detail below in conjunction with specific embodiments. It should be understood that the specific implementations described in this specification are only for explaining the present invention, not for limiting the present invention.

[0066] The experimental materials and reagents used, unless otherwise specified, are conventional consumables and reagents that can be obtained from commercial channels.

[0067] Chinese herbal medicine

[0068] Scutellaria baicalensis, peony root, licorice root, and red date were purchased from a pharmacy in Guangzhou, Guangdong, China, and identified by experts in traditional Chinese medicine.

[0069] Using ultra-high performance liquid chromatography (UPLC) to analyze and confirm that the content of baicalin in Scutellaria baicalensis is 13.19%, the content of paeoniflorin in Radix Pa...

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Abstract

The invention discloses application of scutellaria baicalensis decoction in preparation of medicines for treating diarrhea and improving intestinal functions. The scutellaria baicalensis decoction comprises scutellaria baicalensis, Chinese herbaceous peony, liquorice and red dates. According to the radix scutellariae decoction disclosed by the invention, mRNA expression of AQP3 and NHE8 can be reduced, and the ratio level of intestinal flora Firmicutes/Bacteroidetes (F/B) is reduced to be close to the normal level, so the diarrhea symptom is relieved. Moreover, the radix scutellariae decoction can also effectively improve intestinal flora, and the high-dose traditional Chinese medicine composition increases the relative abundance of candida mycoderma bacteria and enhances the immunocompetence of intestinal epithelium; the low-dose traditional Chinese medicine composition increases the relative abundance of the Jeotgaliccus and promotes the intestinal health.

Description

technical field [0001] The invention belongs to the application field of traditional Chinese medicine compositions, and in particular relates to the application of Huangqin Decoction in the preparation of medicines for treating diarrhea and improving intestinal function. Background technique [0002] Acute diarrhea is a global public health problem. The drugs traditionally used to treat acute diarrhea are mainly antibiotics, but in recent years, due to problems such as antibiotic resistance, the research direction has begun to turn to the antidiarrheal potential of plant compounds. [0003] Huangqin Decoction is a traditional Chinese medicine formula that first appeared in the TCM treatise "Treatise on Febrile Diseases" and was widely used in Eastern countries more than 1,800 years ago to treat gastrointestinal symptoms, including abdominal cramps, fever, headache, vomiting, nausea, and extreme thirst , Heart swelling and so on. However, the actual applicable diseases and ...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/725A61P1/12A61P1/00
CPCA61K36/539A61K36/71A61K36/65A61K36/484A61K36/725A61P1/12A61P1/00
Inventor 彭新宇康桦华陈文露徐志宏袁明贵向蓉田雅周廷斤魏琦麟
Owner INST OF ANIMAL HEALTH GUANGDONG ACADEMY OF AGRI SCI
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