Method and equipment for preparing micronized medicines by using microreactor

A microreactor and reactor technology, applied in the direction of granulating raw materials, chemical instruments and methods, chemical/physical/physicochemical reactors, etc., can solve severe collisions, unfavorable drug generation or crystallization, and liquid reaction. Flow or not fully reacted into the sample pipeline and other issues

Active Publication Date: 2021-07-30
HUBEI POLYTECHNIC UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the problem with the above-mentioned equipment is that the sampling pipeline is directly connected to the micro-reaction space, and there are violent molecular collisions between different liquids, which will cause the liquid to flow back or enter the sampling pipeline without sufficient reaction. It is beneficial to the generation or crystallization of the target drug. Although the amount of raw materials and reagents entering the micro-react

Method used

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  • Method and equipment for preparing micronized medicines by using microreactor
  • Method and equipment for preparing micronized medicines by using microreactor
  • Method and equipment for preparing micronized medicines by using microreactor

Examples

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Embodiment 1

[0034] This embodiment provides a microreactor for producing micronized medicine, see Figure 1-3 , including a reactor main body, a plurality of raw material boxes 1, and a collection box 2. Different raw material boxes 1 are used to hold different liquids, such as reaction raw materials, reaction reagents, solvents, catalysts, etc. for producing medicines. The main body of the reactor is used for Micro-reaction, drying and other operations are carried out. The upper end of the main body of the reactor is respectively connected with a plurality of raw material boxes 1, and the lower end is connected with the collection box 2. The collection box 2 is used to collect the prepared micronized medicine. The main body of the reactor, a plurality of raw material boxes 1 and collection boxes 2 are installed on the brackets respectively.

[0035] The structure of the reactor main body is as follows, including a protective shell 3 , a sample injection tube 31 , a flow guide table 32 , ...

Embodiment 2

[0040] A kind of method utilizing microreactor to prepare micronized medicine, comprises the following steps:

[0041] First, select appropriate raw materials according to the structure and characteristics of the target drug, and prepare a raw material solution and a reaction reagent solution. Each raw material box 1 contains a liquid, and the pump 311 is in a closed state at this time;

[0042] Second, open all pumps 311 and control different liquids to flow at different flow rates. For example, when the raw material solution for preparing medicine is one and the reaction reagent solution is also one, the ratio of the flow rate of the control raw material solution to the reaction reagent solution is 1:80-100; when the pump 311 is turned on, the drug is gradually generated in the reaction chamber 33, and then flows out in a trickle through the drainage tube 34. Since this process has a delay in the reaction time, the opening time of the dryer 35 can be at the same time as the p...

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Abstract

The invention belongs to the technical field of medicine production, and particularly relates to a method and equipment for preparing micronized medicines by using a microreactor. The method is carried out by using a microreactor, and the microreactor comprises: a plurality of raw material boxes; a reactor main body which comprises a protective shell, a sample injection pipe, a flow guide table, a reaction cavity, drainage pipes and a dryer, wherein the flow guide table is installed in the protective shell and is a double-layer sleeve, a plurality of vertical flow guide grooves are formed in the outer side wall of an inner-layer pipe of the sleeve, the reaction cavity is reserved between the bottom wall of an outer-layer pipe and the bottom wall of the inner-layer pipe of the flow guide table, the bottom of the reaction cavity is communicated with the multiple drainage pipes, and the dryer is arranged at the bottoms of the drainage pipes; and a collecting box which is communicated with the drying cavity through a powder collecting pipeline. The flow guide table, the reaction cavity and the drainage pipes capable of buffering liquid molecule collision are arranged between the sample injection pipe and the reaction cavity, so that the molecule collision speed is reduced, and the problem that liquid flows back into the sample injection pipeline or flows into a sample discharge pipeline early is solved.

Description

technical field [0001] The invention belongs to the technical field of medicine production, and in particular relates to a method and equipment for preparing micronized medicine by using a microreactor. Background technique [0002] Ultra-fine powder drugs have advantages that cannot be compared with conventional drugs. Through micronization of drugs, water solubility can be improved and drug bioavailability can be improved. The micronization methods of different drugs are different. At present, the most common methods are ultrafine pulverizer pulverization technology and micro-reactor micro-reaction technology. It is used for brewing, without decoction and pharmaceutical operation of Chinese medicinal materials, which is convenient for patients to operate and take quickly; another example is the preparation of cefuroxime axetil micropowder by combining the micro-reaction technology of micro-reactor with the method of anti-solvent recrystallization , taking advantage of the...

Claims

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Application Information

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IPC IPC(8): B01J19/00B01D1/18B01D1/20B01D1/00B01J2/00B01J2/02
CPCB01J19/0093B01J19/0053B01J2/00B01J2/02B01D1/20B01D1/18B01D1/00
Inventor 谢小银刘冠辰左小华邓祥义
Owner HUBEI POLYTECHNIC UNIV
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