Method and equipment for preparing micronized medicines by using microreactor

Abstract

The invention belongs to the technical field of medicine production, and particularly relates to a method and equipment for preparing micronized medicines by using a microreactor. The method is carried out by using a microreactor, and the microreactor comprises: a plurality of raw material boxes; a reactor main body which comprises a protective shell, a sample injection pipe, a flow guide table, a reaction cavity, drainage pipes and a dryer, wherein the flow guide table is installed in the protective shell and is a double-layer sleeve, a plurality of vertical flow guide grooves are formed in the outer side wall of an inner-layer pipe of the sleeve, the reaction cavity is reserved between the bottom wall of an outer-layer pipe and the bottom wall of the inner-layer pipe of the flow guide table, the bottom of the reaction cavity is communicated with the multiple drainage pipes, and the dryer is arranged at the bottoms of the drainage pipes; and a collecting box which is communicated with the drying cavity through a powder collecting pipeline. The flow guide table, the reaction cavity and the drainage pipes capable of buffering liquid molecule collision are arranged between the sample injection pipe and the reaction cavity, so that the molecule collision speed is reduced, and the problem that liquid flows back into the sample injection pipeline or flows into a sample discharge pipeline early is solved.

Description

technical field [0001] The invention belongs to the technical field of medicine production, and in particular relates to a method and equipment for preparing micronized medicine by using a microreactor. Background technique [0002] Ultra-fine powder drugs have advantages that cannot be compared with conventional drugs. Through micronization of drugs, water solubility can be improved and drug bioavailability can be improved. The micronization methods of different drugs are different. At present, the most common methods are ultrafine pulverizer pulverization technology and micro-reactor micro-reaction technology. It is used for brewing, without decoction and pharmaceutical operation of Chinese medicinal materials, which is convenient for patients to operate and take quickly; another example is the preparation of cefuroxime axetil micropowder by combining the micro-reaction technology of micro-reactor with the method of anti-solvent recrystallization , taking advantage of the...

AI Technical Summary

Problems solved by technology

However, the problem with the above-mentioned equipment is that the sampling pipeline is directly connected to the micro-reaction space, and there are violent molecular collisions between different liquids, which will cause the liquid to flow back or enter the sampling pipeline without sufficient reaction. It is beneficial to the generation or crystallization of the target drug. Although the amount of raw materials and reagents entering the micro-reaction space can be controlled by controlling the flow rate, the control of the flow rate can only reduce the unreacted liquid from entering the sample outlet pipeline, reducing the waste of raw materials. Equipment The structure itself still has the risk of violent molecular collisions. Since different raw materials may be suitable for different flow rates, this requires a large number of experiments to obtain the optimal parameters, which consumes time.

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