A kind of preparation method of icodextrin

A technology of icodextrin and preparation method, which is applied in the direction of sustainable manufacturing/processing, climate sustainability, chemical industry, etc., can solve the problems of complex icodextrin purification process, unsuitability for industrial production, and high cost, and achieve Reduce the production of insoluble starch granules, the process is stable and easy to control, and the effect of mild reaction

Active Publication Date: 2022-05-31
ZIBO QIANHUI BIOTECH
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Problems solved by technology

[0007] The Chinese patent with the publication number CN106755199A prepares icodextrin by enzymatic hydrolysis, and the purification process is complex and costly, and is not suitable for industrial production

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  • A kind of preparation method of icodextrin
  • A kind of preparation method of icodextrin

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Abstract

A method for preparing icodextrin, belonging to the technical field of cyclodextrin production, comprising: gelatinization, acidolysis, decolorization and ultrafiltration processes in sequence, characterized in that: the gelatinization process includes mixing insoluble organic particles, starch and The water is mixed and stirred at 90-100°C, and the slurry is adjusted at normal temperature, wherein the added amount of the insoluble organic particles is 1-2% of the weight of the starch. The insoluble organic particles are polystyrene microspheres, insoluble cellulose particles or poly(N-isopropylacrylamide) microgel particles. Compared with the prior art, the starch liquid is gelatinized before the acid hydrolysis, and insoluble organic particles are added in the gelatinization to make the starch disperse evenly, prevent the aging of the starch, reduce the generation of insoluble starch particles, and improve the conversion rate and yield of the product .

Description

A kind of preparation method of icodextrin technical field The present invention relates to a kind of preparation method of icodextrin, belong to cyclodextrin production technical field. Background technique As the main active ingredient of peritoneal dialysate, icodextrin is starch through α-(1-4) and less than 10% α (1-6) The water-soluble glucose polymer linked by glycosidic bonds, the weight-average molecular weight is 13000-19000Da, and the number-average molecular weight is 5000‑6500Da. The icodextrin peritoneal dialysis solution (Extraneal) that Baxter company produces has been approved in Japan in 2003 city. As a glucose polymer, icodextrin can be degraded into small molecular polymers by starch acid hydrolysis, lye hydrolysis or enzymatic hydrolysis. After molecular weight screening, icodextrin was obtained. Publication number is that the Chinese patent of CN103467608A discloses a kind of icodextrin and preparation method thereof, preparation method T...

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08B30/18
CPCC08B30/18Y02P20/10
Inventor 许维成王丽萍崔丽艳王哲刘涛
Owner ZIBO QIANHUI BIOTECH
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