Application of tricin in preparation of external preparation for intervening skin light injury

A technology of wheat flavonoids and external preparations, applied in the fields of skin photodamage agents and medicine, to achieve the effects of alleviating skin photodamage symptoms, broad clinical application prospects, and inhibiting expression

Inactive Publication Date: 2021-08-20
NANTONG UNIVERSITY
View PDF1 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there has been no report on the use of wheat xanthin to repair skin photodamage

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of tricin in preparation of external preparation for intervening skin light injury
  • Application of tricin in preparation of external preparation for intervening skin light injury
  • Application of tricin in preparation of external preparation for intervening skin light injury

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] A representative external preparation for intervening skin photodamage, which is composed of the following ingredients: 3.5% wheat xanthin, 49% purified water, 10% 1,2-propanediol, 5% ethanol, polydimethylsiloxane Oxane 7%, PEG 8000 25%, Methylparaben 0.5%. The percentages of the above substances are mass ratios.

[0023] Preparation method: Heat the prescribed amount of wheat flavin, 1,2-propylene glycol, ethanol and methylparaben to 50°C to fully dissolve into a clear and transparent solution, which is mixture A; mix purified water, polydimethylsiloxane After heating with PEG 8000 to 50°C, mechanically stir and fully homogenize to form mixture B; while it is hot, stir at high speed and drop mixture A into mixture B slowly, stir evenly and then cool down to room temperature to obtain the external preparation described in this example .

[0024] How to use: Take an appropriate amount and apply it to the skin directly, once a day, without washing, and apply moisturizin...

Embodiment 2

[0026] A representative external preparation for intervening skin photodamage, which is composed of the following ingredients: 3.5% wheat yellowin, 44% purified water, 9% 1,2-propanediol, 6% ethanol, polydimethylsiloxane 7% oxane, 15% glyceryl monostearate, 15% polyoxyethylene castor oil (Cremophor EL), 0.5% methylparaben. The percentages of the above substances are mass ratios.

[0027] Preparation method: Heat the prescribed amount of wheat flavin, 1,2-propylene glycol, ethanol and methylparaben to 50°C to fully dissolve into a clear and transparent solution, which is mixture A; mix purified water, polydimethylsiloxane , Glyceryl monostearate, and polyoxyethylene castor oil (Cremophor EL) were heated to 50°C, mechanically stirred and fully homogenized to form mixture B; while it was hot, slowly add mixture A to mixture B and stir evenly After cooling down to room temperature, the external preparation described in this example was obtained.

[0028] How to use: Take an appr...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention belongs to the technical field of medicines, particularly relates to the technical field of skin light injury medicaments, and discloses application of tricin in preparation of an external medicine for preventing and / or treating skin light injury. The invention also discloses an external preparation for preventing and / or treating skin light injury, which is characterized in that the external preparation at least comprises tricin and can also comprise medically acceptable auxiliary materials. According to the embodiment of the invention, experimental results show that the tricin can improve the proliferative activity of fibroblasts, inhibit the expression of MMP-1 and MMP-3, reduce the degradation of an extracellular matrix, obviously relieve the skin light injury symptom, can be used for preparing an external medicine for intervening skin light injury, and has a wide clinical application prospect.

Description

technical field [0001] The invention belongs to the technical field of medicine, in particular to the technical field of skin photodamage medicaments, and in particular to the application of wheat xanthin in the preparation of external preparations for intervening skin photodamage. Background technique [0002] On a daily basis, parts of the human body are exposed to sunlight. Due to different lifestyles and work types, excessive sun exposure can cause a series of damage to the skin, which is mainly caused by excessive exposure to ultraviolet rays in the sun, especially medium-wave ultraviolet (UVB). The wavelength of UVB is 290-320nm, with medium penetrating power. Most of the UVB contained in sunlight is absorbed by the ozone layer, and less than 2% can reach the surface of the earth, which is particularly strong in summer and afternoon. UVB has an erythema effect on the human body. Although it can promote mineral metabolism and the formation of vitamin D in the body, lon...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K31/352A61K45/06A61P17/16A61P17/18
CPCA61K31/352A61K45/06A61P17/16A61P17/18
Inventor 金飞程诗涵
Owner NANTONG UNIVERSITY
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap