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3D printing-based calcium phosphate ceramic high-throughput screening model and preparation method and application thereof

A calcium phosphate ceramic and 3D printing technology, applied in the field of biomedical engineering, can solve the problems of poor induction performance of calcium phosphate ceramics, and achieve the effect of shortening the evaluation period, high reliability and good application prospects.

Pending Publication Date: 2021-08-24
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] One of the purposes of the present invention is to provide a high-throughput screening model for calcium phosphate ceramics based on 3D printing, which can realize high-throughput preparation of 3D printed calcium phosphate ceramics and be applied to high-throughput evaluation of osteoinductive properties of materials , screen and optimize the osteoinductive parameters of calcium phosphate ceramics, and solve the problem of poor induction performance of 3D printed calcium phosphate ceramics

Method used

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  • 3D printing-based calcium phosphate ceramic high-throughput screening model and preparation method and application thereof
  • 3D printing-based calcium phosphate ceramic high-throughput screening model and preparation method and application thereof
  • 3D printing-based calcium phosphate ceramic high-throughput screening model and preparation method and application thereof

Examples

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Embodiment 1

[0054] This example discloses the preparation of calcium phosphate ceramic high flux screening model for different porosity structures and porosity, and investigates the effects of different pore geometries and porosity on calcium phosphate ceramic bone inducing properties. The method of preparing the calcium phosphate ceramic high flux screening model of the present invention, including the following steps:

[0055] (1) Model design:

[0056] The calcium phosphate ceramic high flux screen is designed by computer model. The model of the present embodiment is made of the same material, considering shrinkage after sintering, and to ensure the screening experiment, the design model is 17mm, height 34mm. The model includes four types of porosity, each geometric structure comprising 6 porosity, the same vertical direction of different porosity of the same geometry, is sequentially distributed in the porosity size, such as attached figure 1 As shown in: 1 The screening unit of the colum...

Embodiment 2

[0066] This example discloses the preparation of calcium phosphate ceramic high flux screening model for the preparation of different substances and pore geometries, and investigated the effects of different substance components and pore geometric structures on calcium phosphate ceramic induction performance. The method of preparing the calcium phosphate ceramic high flux screening model of the present invention, including the following steps:

[0067] This example discloses a method of preparing a 3D printing high-throughput phosphate ceramic screening model of the present invention, including the following steps:

[0068] (1) Model design:

[0069] The high flux model of calcium phosphate ceramic is designed by computer model design software, and the material parameters of each screening unit of the model are different. Considering the contraction after the material is sintered, the design model size is 17mm in diameter and a height of 34 mm. The model includes four kinds of ape...

Embodiment 3

[0079] This example discloses the preparation of different aperture geometries and porecalic acid calcium phosphate ceramic high flux screening models, and investigated different pore geometries and aperture parameters on the induction performance of calcium phosphate ceramic bone. The method of preparing the calcium phosphate ceramic high flux screening model of the present invention, including the following steps:

[0080] (1) Model design:

[0081] The calcium phosphate ceramic high flux screen is designed by computer model. The model of the present embodiment is made of the same material, considering shrinkage after sintering, and to ensure the screening experiment, the design model is 17mm, height 34mm. This model includes four types of geometries, each of which includes 6 different aperture sizes. The same longitudinal distribution of different aperture sizes of the same hole geometry. The four kinds of hole geometry are respectively pair of frame holes, diamond structures, ...

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Abstract

The invention belongs to the technical field of biomedical engineering, and discloses a 3D printing-based calcium phosphate ceramic high-throughput screening model and a preparation method and application thereof. The 3D printing-based calcium phosphate ceramic high-throughput screening model is calcium phosphate ceramic prepared from original ceramic powder through 3D printing, and comprises a plurality of screening units with different material parameters or / and pore structure parameters. The preparation method comprises the following steps: designing a model; preparing light-cured ceramic 3D printing slurry; performing 3D printing to obtain a ceramic body; and degreasing and sintering the ceramic body to obtain the calcium phosphate ceramic high-throughput screening model based on 3D printing. The invention further provides application of the high-throughput screening model in screening of bone induction materials. The calcium phosphate ceramic high-throughput screening model integrating multi-structure and multi-component characteristics is designed and obtained, high-efficiency and low-cost calcium phosphate ceramic high-throughput preparation and biological evaluation are achieved, and the model has good application prospects in the field of biomedical materials.

Description

Technical field [0001] The present invention belongs to the field of biomedical engineering, and in particular, the present invention relates to a 3D printing of calcium phosphate ceramic high flux screening model and method for formulation. Background technique [0002] The chemical composition of calcium phosphate biocarbon is close to the inorganic component of the human bone, not only having better biocompatibility, but also a large number of studies have confirmed that it has good bone inducerability, which induces good bone regenerative ability, and thus in the clinic It has been widely used in applications. Typically, bone inductivity of biomaterials refers to an ectopic induction of ectopic induction of subcutaneous or muscles of animals. Therefore, through the optimization design of the material itself, fully mobilize the self-repairing ability of the body, induce the healing regeneration of the lesion defect, and achieve permanent rehabilitation of damaged tissue and or...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C04B35/447C04B35/622C04B38/00B28B1/00B33Y80/00B33Y70/10B33Y10/00A61L27/10A61L27/12A61L27/56
CPCC04B35/447C04B35/622C04B38/00B28B1/001B33Y80/00B33Y70/10B33Y10/00A61L27/10A61L27/12A61L27/56A61L2430/02C04B2235/3208C04B2235/6562C04B2235/6567C04B2235/6026C04B2235/5445C04B2235/5436C04B38/0054
Inventor 朱向东吴永豪王璟李向锋曹全乐陈雪宁张兴栋
Owner SICHUAN UNIV
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