Lornoxicam sodium chelate and its preparation method and application
A technology of lornoxicam sodium and lornoxicam, applied in the field of medicine, can solve the problems of slow dissolution rate, low solubility of lornoxicam and the like
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Embodiment 1
[0040] 1.2g of sodium hydroxide was added to 60mL of 95% methanol, dissolved at room temperature to obtain a clear solution, and then 11.16g of lornoxicam was added to ultrasonically dissolve to obtain a yellow solution. The yellow solution was concentrated by vacuum steaming at a temperature of 55 ° C, about 5 minutes after the concentrated solution was placed in an ice water bath, let stand for 3 hours and then filtered to obtain a yellow solid, 25 ° C vacuum drying for 24 hours, you can obtain lornoxicam sodium chelate.
Embodiment 2
[0042] 1.2g of sodium hydroxide was added to 80mL of 90% acetonitrile, dissolved at room temperature to obtain a clear solution, and then 11.16g of lornoxicam was added to sonicate to obtain a yellow solution. The yellow solution was placed in an ice water bath, left for 4 hours and then filtered to obtain a yellow solid, and the 30 °C vacuum was dried for 24h to obtain lornoxicam sodium chelate.
Embodiment 3
[0044] 1.2g of sodium hydroxide was added to 90mL of ethanol, dissolved at room temperature to obtain a clear solution, and then 11.16g of lonoxican was added to sonicate to obtain a yellow solution. The yellow solution is concentrated by vacuum rotation, the temperature is 60 ° C, about 5 minutes after the concentrated solution is placed in an ice water bath, standing for 3 hours after filtering, to obtain a yellow solid, 35 ° C vacuum drying for 24 hours, you can get lornoxicam sodium chelate.
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